Medication rules and mechanism of action analysis of traditional Chinese medicine in the treatment of coronary heart disease combined with hyperlipidemia based on R language data mining and network pharmacology
OBJECTIVE To explore and analyze medication rules of TCM treating coronary heart disease combined with hyperlipidemia,further to predict potential mechanisms of action of core drug combinations treat coronary heart disease combined with hyperlipidemia.METHODS Relevant literature was searched on the treatment of coronary heart disease combined with hyperlipidemia by TCM in Chinese databases,and a prescription database was established.R language for drug frequency statistics and association rules analysis was applied;key active ingredients and core targets was screened by Cytoscape software;GO function and KEGG enrichment were analyze by Metascape platform to explore the biological processes and related pathways of core drug combinations to treat the disease to elucidate the mechanism of action;key active ingredients and key core targets were ralidated using molecular docking technology.RESULTS A total of 62 prescriptions with 134 herbs were obtained after the screening.The analysis of association rules that Salvia miltiorrhiza-Crataegus pinnatifida-Pinellia ternata(SCP)was a core drug combination with strong association.There were 86 active ingredients and 155 potential targets for the treatment of coronary heart disease combined with hyperlipidemia in the SCP,with 16 main active ingredients and 33 core targets obtained by topological analysis.KEGG enrichment analysis suggested that mainly involved in lipid and atherosclerotic pathways,fluid shear stress,Th17 cell differentiation,and IL-17 and so on various signaling pathways were.Molecular docking results showed that the key active ingredients docked well with the key core targets,with the best combination between luteolin and AKT1,IL6,VEGFA,TP53,and PPARG.CONCLUSION The prescription of TCM for the treatment of coronary heart disease combined with hyperlipidemia is based on resolving phlegm and lowering turbidity,activating blood circulation,and removing blood stasis.SCP in the treatment of this disease may function through a variety of mechanisms.
R languageData miningNetwork pharmacologyMolecular dockingTraditional Chinese MedicineCoronary heart disease complicated with hyperlipidemiaSalvia miltiorrhiza-Crataegus pinnatifida-Pinellia ternataMechanism of action
万方数据
维普
