The in situ gel is an environmentally sensitive drug delivery system.It can be categorized as thermo-sensitive,pH-sensitive,and ion-sensitive with different materials.The performance of the gel is not only closely related to the type of gel but also influenced by the type of matrix.This review summarizes the application of different matrices in the development of in situ gel formulations,including chitosan,poloxamer,and gellan gum,and points out the issues related to gel types and matrices,providing references and insights for the development of related formulations.
关键词
原位凝胶/胶凝机理/壳聚糖/泊洛沙姆/卡波姆/蚕丝蛋白/海藻酸钠/结冷胶
Key words
In situ gel/Mechanism/Chitosan/Poloxamer/Carbopol/Silk fibroin/Sodium alginate/Gellan gum
维普
万方数据