Research progress on in situ gel matrix based on environmental response
The in situ gel is an environmentally sensitive drug delivery system.It can be categorized as thermo-sensitive,pH-sensitive,and ion-sensitive with different materials.The performance of the gel is not only closely related to the type of gel but also influenced by the type of matrix.This review summarizes the application of different matrices in the development of in situ gel formulations,including chitosan,poloxamer,and gellan gum,and points out the issues related to gel types and matrices,providing references and insights for the development of related formulations.
In situ gelMechanismChitosanPoloxamerCarbopolSilk fibroinSodium alginateGellan gum
万方数据
维普
