Naturally Degradable Sustained-release Microspheres of Polycaprolactone Loaded with Pesticide
Traditional pesticides have a short shelf life and low effective utilization rate.In order to achieve the goal of"reducing application and increasing efficiency",the concept of"sustained-release pesticide"is proposed.At present,the sustained-release microcapsules of pesticide in the market are mostly made of synthetic polymer materials that cannot be naturally degraded.After the release of ac-tive ingredients,they still remain in the environment,causing serious pollution.To address this issue,by using polycaprolactone as the carrier and beta-cypermethrin as the drug model,naturally degradable sus-tained-release microspheres of polycaprolactone loaded with cypermethrin were prepared by O/W sol-vent evaporation method.The effects of solvent evaporation time,centrifugation rate,and drug dosage on the preparation of microspheres were investigated.The maximum drug loading and the maximum encap-sulation efficiency of the prepared microspheres were 49.60%and 97.13%,respectively.The entire pro-cess of drug sustained release did not show sudden release,with a fairly long sustained release time,in-dicating a significant sustained release effect.The Ritger-Peppas model was used to analyze the drug release kinetics,and the results showed that the release mechanism of the microspheres was a combina-tion of drug diffusion and skeleton dissolution diffusion.
polycaprolactonebeta-cypermethrinO/W solvent evaporation methodRitger-Peppas model
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