微生物种群间分工协作在木质纤维素转化中的研究进展
Progress on division of labor and cooperation among microbes in lignocellulose conversion
刘亮 1杨金水 1黄娅茹 1姜婷婷 1余启军 1袁红莉1
作者信息
- 1. 中国农业大学生物学院/畜禽生物育种全国重点实验室/农业农村部土壤微生物学重点实验室,北京 100193
- 折叠
摘要
联合生物加工被认为是木质纤维素转化的最理想形式,虽然通过代谢工程改造可以基于单一菌株实现联合生物加工,但过高的代谢压力导致菌株转化效率并不理想.为了系统认识微生物种间分工和实现联合生物加工的理性设计,本文聚焦于天然木质纤维素降解菌群中的种间分工,从底物协同水解、营养因子交叉喂养和"糖骗子"限制的角度综述了目前物种间的分工协作模式,介绍了物种分工在木质纤维素转化中的应用,以及天然木质纤维素菌群中种间分工研究的挑战和未来发展方向,为联合生物加工菌群的构建提供设计原则,推动木质纤维素的高效转化.
Abstract
Consolidated bioprocessing(CBP)is considered as the most ideal form for lignocellulose conversion.Although the modification of metabolic engineering can achieve CBP based on a single strain,excessive metabolic pressure alone leads to the suboptimal transformation efficiency of strain.This article fo-cused on the interspecific division in the microbial community of degrading natural lignocellulosic to system-atically understand the interspecific division of labor and realize the rational design of CBP.The current pat-terns of interspecific division of labor were reviewed in terms of the synergistic hydrolysis of substrate,the cross-feeding of nutritional factors,and the restriction of"sugar cheaters".The application of interspecific division of labor in lignocellulose conversion,the challenges and development directions of studying inter-specific division in microbial communities of natural lignocellulose were introduced.It will provide principles for designing the construction of a microbial community with consolidated bioprocessing to promote the effi-cient biotransformation of lignocellulose.
关键词
微生物菌群/种间分工/木质纤维素转化/联合生物加工/人工菌群Key words
microbial communities/interspecific division of labor/lignocellulose conversion/consoli-dated bioprocessing/synthetic consortium引用本文复制引用
基金项目
畜禽生物育种全国重点实验室开放课题(2024SKLAB6-7)
出版年
2024
NETL
NSTL
万方数据