专性捕食细菌蛭弧菌及其类似细菌(Bdellovibrio and like organisms,BALOs)因在农业、工业和医学,尤其是在治疗抗生素耐药病原细菌感染中的潜在应用前景而倍受重视.但关于BALOs的诸多基础科学问题在过去几十年里一直不清楚,这也是这类细菌暂未被有效开发和利用的根本原因.近年来,关于BALOs生命周期、捕食机制、资源分布与多样性以及它们在医学、农业和工业中的应用等方面取得了较多进展,特别是2021年蛭弧菌门正式确立以来,相关研究暴发式增长.本文系统回顾BALOs的研究进展,并着重介绍最新报道的捕食机制研究等突出成就,以促进我们对BALOs资源的认识与进一步应用,并指导未来的 BALOs 研究.
Predation mechanism and potential application of specific predatory bacteria:Bdellovibrio and like organisms
The specific predatory bacteria Bdellovibrio and like organisms(BALOs)are been highly valued due to their potential applications in agriculture,industry and medicine,especially in treating the in-fections caused by pathogenic bacteria with antibiotic resistance.However,many fundamental scientific is-sues regarding BALOs have been unclear in the past decades,which is the bottom cause why these types of bacteria have not been effectively developed and utilized yet.In recent years,significant progress has been made in the life cycle,mechanisms of predation,the distribution of resource and the diversity of BA-LOs,and the applications of BALOs in medicine,agriculture,and industry.Especially since the formal es-tablishment of the phylum Bdellovibrionota in 2021,there has been an explosive growth in studies related to BALOs.This article systematically reviewed the progress on studying BALOs.It was focused on intro-ducing the latest reports on predatory mechanisms of BALOs and other outstanding achievements to pro-mote the understanding and further application of BALOs resources,and to guide the studies on BALOs in the future.
predatorBdellovibrio bacteriovorusBdellovibrio and like organisms(BALOs)mi-crobial resourcesantibiotic resistance
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