miRNA在乳腺癌中的研究进展
Research progress of miRNA in breast cancer
雷志鑫 1杨海旖 1谢浩 1环世娇 1孙涛垒1
作者信息
- 1. 武汉理工大学化学化工与生命科学学院/神经退行性疾病纳米医药湖北省重点实验室,武汉 430070
- 折叠
摘要
乳腺癌是全球3种最常见的癌症之一,对人类健康构成严重威胁.MicroRNA(miRNA)作为一种基因调控的小分子,可以介导细胞靶基因调控乳腺癌发生和发展进程.本文根据miRNA的来源进行分类并综述了当前已知内源性与外源性miRNA(植物元)的功能特性,并探讨这些miRNA在乳腺癌调控中的作用机制.同时,运用生物信息学预测乳腺癌相关的外源性miRNA潜在靶点,旨在为miRNA在乳腺癌治疗中的应用提供参考.
Abstract
Breast cancer is one of the three most common cancers with the highest mortality rate in the world and poses a serious threat to human health.MicroRNA(miRNA),as a small molecule of gene regulation,can mediate cellular target genes to regulate the occurrence and development of breast cancer.In this paper,we classified miRNA according to their sources,reviewed the currently known functional proper-ties of endogenous and exogenous miRNA(botanmin),and explored their regulatory mechanisms in breast cancer.At the same time,the potential targets of exogenous miRNA associated with breast cancer were pre-dicted by bioinformatics,which provided a reference for their application in breast cancer therapy.
关键词
miRNA/乳腺癌/抗肿瘤/基因调控/植物元Key words
miRNA/breast cancer/antitumor/gene regulation/botanmin引用本文复制引用
出版年
2024
NETL
NSTL
万方数据