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miRNA在乳腺癌中的研究进展

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乳腺癌是全球3种最常见的癌症之一,对人类健康构成严重威胁.MicroRNA(miRNA)作为一种基因调控的小分子,可以介导细胞靶基因调控乳腺癌发生和发展进程.本文根据miRNA的来源进行分类并综述了当前已知内源性与外源性miRNA(植物元)的功能特性,并探讨这些miRNA在乳腺癌调控中的作用机制.同时,运用生物信息学预测乳腺癌相关的外源性miRNA潜在靶点,旨在为miRNA在乳腺癌治疗中的应用提供参考.
Research progress of miRNA in breast cancer
Breast cancer is one of the three most common cancers with the highest mortality rate in the world and poses a serious threat to human health.MicroRNA(miRNA),as a small molecule of gene regulation,can mediate cellular target genes to regulate the occurrence and development of breast cancer.In this paper,we classified miRNA according to their sources,reviewed the currently known functional proper-ties of endogenous and exogenous miRNA(botanmin),and explored their regulatory mechanisms in breast cancer.At the same time,the potential targets of exogenous miRNA associated with breast cancer were pre-dicted by bioinformatics,which provided a reference for their application in breast cancer therapy.

miRNAbreast cancerantitumorgene regulationbotanmin

雷志鑫、杨海旖、谢浩、环世娇、孙涛垒

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武汉理工大学化学化工与生命科学学院/神经退行性疾病纳米医药湖北省重点实验室,武汉 430070

miRNA 乳腺癌 抗肿瘤 基因调控 植物元

2024

华中农业大学学报
华中农业大学

华中农业大学学报

CSTPCD北大核心
影响因子:1.09
ISSN:1000-2421
年,卷(期):2024.43(5)