Study on Colon-targeted Oral Nanomedicine Based on Zein-HA Carrier
Oral nanocarriers for colon-targeted medicine delivery based on Zein-hyaluronic acid(HA)were designed in this study.The nanomedicine of Zein-HA-hydroxycamptothecin(Zein-HA@HCPT)was prepared by the ultrasound dialysis method.The preparation conditions of the nanomedicine were optimized by desirability function.The microstructure,drug release behavior,cytotoxicity and targeted cellular uptake ability of the nanomedicine were investigated.The results showed that Zein-HA@HCPT possessed a high drug encapsulation efficiency over 95％.Meantime,it exhibited excellent biological stability,biocompatibility,and unique gastric acid resistance.The cumulative release of drugs in the colonic environment was significantly improved.Furthermore,Zein-HA@HCPT was targeted and taken up by colon cancer cells through CD44 receptor mediated endocytosis,which can improve the anti-tumor efficacy of drugs.
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