菏泽学院学报2024,Vol.46Issue(5) :123-128.

丹皮酚对大鼠空肠运动的影响

The Effect of Paeonol on the Jejunum Motility of Rat

路雯 刘维豪 胡晨晨 翟珂晗 张贵生
菏泽学院学报2024,Vol.46Issue(5) :123-128.

丹皮酚对大鼠空肠运动的影响

The Effect of Paeonol on the Jejunum Motility of Rat

路雯 1刘维豪 2胡晨晨 1翟珂晗 1张贵生1
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作者信息

  • 1. 菏泽学院农业与生物工程学院,山东菏泽 274015
  • 2. 山东大树达孚特膳食品有限公司,山东菏泽 274015
  • 折叠

摘要

实验选取健康SD大鼠作为研究对象,研究了丹皮酚对大鼠空肠运动功能的影响.大鼠麻醉后取出大约2 cm长的空肠组织,采用Krebs液进行离体组织灌流保持其生理活性.在灌流液中加入不同剂量的丹皮酚溶液,观察丹皮酚对肠段自发收缩运动的作用,加入乙酰胆碱诱发空肠高张力收缩,而后再加丹皮酚,观察丹皮酚对乙酰胆碱诱发性收缩的作用.研究结果显示丹皮酚对大鼠空肠的自发性收缩与诱发性收缩皆有舒张作用.

Abstract

A Healthy SD rat is selected as the research object to study the effect of paeonol on the jeju-nal motility function.Approximately 2cm of jejunal tissue is extracted from the anesthetized rat and per-fused with Krebs solution to maintain its physiological activity.In the perfusion fluid,different doses of paeonol solution are added,and the effect of paeonol on spontaneous contraction of intestinal segments is observed.Then,acetylcholine is added into the perfusion fluid to induce high tension contraction of the je-junum.After that,the experiment adds paeonol and observes its effect on acetylcholine induced contrac-tions.The results show that paeonol has a relaxing effect on both spontaneous and induced contractions of the rat jejunum.

关键词

丹皮酚/空肠/舒张作用

Key words

paeonol/jejunum/diastolic effect

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出版年

2024
菏泽学院学报
菏泽学院

菏泽学院学报

影响因子:0.404
ISSN:1673-2103
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