Age-related differences in the role of lifestyle for stroke
Objective To investigate whether there are differences in the influence of lifestyle on stroke risk in different age groups in Songjiang district of Shanghai.Methods A total of 31 771 study participants from the Songjiang District in the Shanghai Suburban Adult Cohort and Biobank were selected to calculate their healthy lifestyle scores(including non-smoking,active physical activity,balanced diet,and normal body weight)and were followed until December 31,2021.Cox proportional risk regression and Poisson regression were used to determine the HR(95％CI)and RR(95％CI)of different lifestyle or healthy lifestyle scores associated with stroke in various baseline age groups and exposed age groups,respectively.Baseline age was stratified by young(20-＜62 years),middle(62-＜68 years),and old(≥68 years)groups.Exposure age was stratified by young(20-＜65 years),middle(65-＜70 years),and old(≥70 years)groups.Results Over a median follow-up of 5.0 years,488 participants developed stroke.After adjusting confounding factors,the associations between non-smoking,active physical activi-ty,balanced diet,or normal body weight and the risk of stroke were not significantly different across age groups,regardless of the method used.The risk of stroke was lower in the group with a score of ≥3 in the young,middle,and old stratum compared with the group with a baseline lifestyle score≤1(HR=0.67,95％CI:0.43-1.03,P=0.072;HR=0.59,95％CI:0.39-0.91,P=0.015;HR=0.64,95％CI:0.42-1.00,P=0.043;RR=0.63,95％CI:0.42-0.96,P=0.028;RR=0.61,95％CI:0.40-0.94,P=0.023;RR=0.63,95％CI:0.40-0.99,P=0.045).Conclusions No age-related differences in the association of different lifestyles with stroke are found among residents of Songjiang District,Shanghai.It implies that a healthy lifestyle should be emphasized regardless of age.In addition,a healthy lifestyle can substantially reduce the risk of stroke.
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