A cohort study on the changes of serum uric acid in the pre-and post-menopause
Objective To investigate the changes of serum uric acid(SUA)around menopause.Methods The linear and piecewise linear mixed effect models were used to analyze SUA changes in the pre-and post-menopause on the Kailuan Health Examination cohort.Multiplicative interaction effects between baseline age as well as baseline BMI and segmented time periods pre-and post-menopause were also analyzed.Results A total of 3 747 female with 21 223 health examination records from 2006 to 2020(7 health examinations)were included in the analysis.The average age at the first health examination was(46.19±4.11)years,and the median age at menopause was 51(50,53)years.Compared to pre-menopause,SUA increased by 10.15 μmol/L in post-menopause.SUA started to increase gradually from 1 1 years before menopause,with an average annual increase of 1.99 μmol/L;From 5 to 2 years before menopause,SUA increased by an average of 3.30 μmol/L per year;During the 2 years before and after menopause period,SUA increased by an average of 4.60 μmol/L per year.After that,the average annual increase slowed,and after 5 years of menopause,the average annual increase in SUA dropped to 1.77μmol/L.There was an interaction between baseline age＜40 years and the time segments of postmenopausal 2-＜5 years after menopause(Pinteraction=0.009)and 5 years or more after menopause(Pinteraction＜0.001),as well as between baseline age 40-＜45 years and the 2 years before and after menopause(Pinteraction=0.033).Except for age under 40 years,which had an impact on SUA changes during 2 years after menopause,the SUA changes around menopause in other baseline age groups were consistent.There was no multiplication interaction effect between baseline BMI and various time segments around menopause(all Pinteraction＞0.05).Conclusions Menopause has an adverse effect on SUA.Middle-aged women should pay attention to their SUA levels around menopause and adopt proactive prevention and control strategies.
MenopauseSerum uric acidCohort studyBody mass index
NETL
NSTL
万方数据
