湖南省2018年4个县区≥40岁人群骨质疏松症流行病学与影响因素
An epidemiological features and risk factors study of osteoporosis among residents aged 40 and over in four counties of Hunan,2018
刘源 1彭莉红 2殷黎 1胡李平 1金东辉1
作者信息
- 1. 湖南省疾病预防控制中心慢性非传染性疾病预防控制科,长沙 410005
- 2. 中南大学湘雅二医院内分泌科,长沙 410008
- 折叠
摘要
目的 了解湖南省2018年4个县区≥40岁人群中骨质疏松症及骨量低下的检出率与分布特征及骨质疏松症患病危险因素,为防控以及相应卫生资源配置提供数据支持.方法 采用多阶段分层随机抽样方法进行抽样,对研究对象进行问卷调查并对骨密度、身高、体重和腰围进行测量.采用率、构成比、均数等指标进行统计描述,率的比较采用Rao-Scott x2检验.采用SAS 9.4软件的多因素Survey logistic回归分析模型进行危险因素分析.结果 共调查≥40岁人群1 597人,其中男性704人(44.08％),女性893人(55.92％).骨质疏松症患病率为15.37％(95％CI:12.08～18.65),女性(26.95％)高于男性(4.55％)(Rao-Scott x2=54.34,P＜0.001).患病率随年龄增长而增加(Rao-Scott x2=131.00,P＜0.001).骨量低下检出率为 53.33％(95％CI:49.61～57.04,P＜0.001),男、女性骨量低下检出率分别为54.28％和52.01％,性别差异无统计学意义(Rao-Scott x2=0.63,P=0.420).多因素Survey logistic回归分析模型分析提示,与男性患骨质疏松相关的因素有 BMI＜18.5 kg/m2(OR=6.52,95％CI:1.51～28.12,P=0.010),与女性患骨质疏松相关的因素有在45岁前停经(OR=2.47,95％CI:1.53～3.90,P＜0.001)、骨折病史(OR=2.76,95％CI:1.62～4.65,P＜0.001)、BMI＜18.5 kg/m2(OR=17.67,95％CI:2.54～122.87,P=0.004)、≥60岁(OR=11.35,95％CI:3.62～35.56,P＜0.001).结论 湖南省≥40岁人群中骨质疏松症患病水平较高,女性患病风险高于男性.潜在发病的骨量低下人群较大,男女性并重.
Abstract
Objective This research focuses on understanding the epidemiology,prevalence,and associated risks of osteoporosis and low bone mass among individuals aged 40 and over in four counties of Hunan Province.It aims to bolster the efforts in bone health management and osteoporosis prevention in the region.Methods A multi-stage stratified random sampling was conducted for this epidemiological study,encompassing questionnaire survey,bone mass measurement and physical measurement such as body weight and height measurements.Rate,constituent ratio and mean were used for statistical despcrition of the data.Rao-Scott x2test was conducted for rate comparisons,and Survey logistic regression model was used for risk factors analysis.All the statistic procedures mentioned above were conducted by SAS 9.4 software.Results A total of 1 597 subjects were finally investigated,including 704 males(44.08％)and 893 females(55.92％).The overall prevalence of osteoporosis in the cohort was 15.37％(95％CI:12.08-18.65),increasing with age(Rao-Scott x2=131.00,P＜0.001)and higher in females than males(26.95％:4.55％,Rao-Scott x2=54.34,P＜0.001).Low bone mass was prevalent in 53.33％of the population(95％CI:49.61-57.04,P＜0.001),while low bone mass was 54.28％prevalent in the studied males and 52.01％in females,and no statistically signif-icant gender differences was found(Rao-Scott x2=0.63,P=0.420).Risk factors for osteoporosis in males included a BMI＜18.5 kg/m2(OR=6.52,95％CI:1.51-28.12,P=0.010).While in females,they risk factors included menopause before 45(OR=2.47,95％CI:1.53-3.90,P＜0.001),history of fracture(OR=2.76,95％CI:1.62-4.65,P＜0.001),BMI＜18.5 kg/m2(OR=17.67,95％Cl:2.54-122.87,P=0.004),and being aged≥60 years(OR=11.35,95％CI:3.62-35.56,P＜0.001).Conclusions Osteoporosis prevalence is notably high in Hunan Province,particularly among females.The study underscores the significant potential risk for osteoporosis in both genders.
关键词
骨质疏松症/骨量低下/患病率/流行病学Key words
Osteoporosis/Low bone mass/Prevalence/Epidemiology引用本文复制引用
出版年
2024
NETL
NSTL
万方数据