Research progress in the study of HPV E2,E5 oncogenic mechanism and related vaccine
Cervical cancer is one of the common malignancies affecting women worldwide,of which persistent infection with high-risk human papillomavirus(HPV)is the main cause.In the occurrence and development of cervical cancer,in addition to HPV E6,E7 and cervical cancer lesions have a major relationship,some other early proteins such as E2 and E5 also play an essential role.For example,E2 can initiate and maintain viral replication,and E5 can cooperate with E6 and E7 oncoproteins to promote proliferation of infected cells.In this paper,we aim to review the current research progress on the mechanism of HPV E2 and E5 proteins in the development of cervical cancer and the progress of research on E2 and E5 related therapeutic vaccines.
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