Analysis of TRAF1/C5 and TNF-α gene polymorphisms with susceptibility to tuberculosis
Objective To analyze the effects of tumor necrosis factor receptor-associated factor 1(TRAF1)/complement component 5(C5)rs 10818488 and tumor necrosis factor-alpha TNF-α rs 1800629 gene polymorphisms,environmental factors,and their interactions on susceptibility to tuberculosis(TB).Methods The TB-confirmed patients in TB-prone families were selected as the case(TB)group.And the healthy volunteers who had medical checkups in the local community during the same period of time were selected as the healthy controls(HC)group.Besides and those who were related to the TB group and lived together were selected as the healthy household contacts(HHC)group.The association of genotype and environmental factors with TB was analyzed by a logistic regression analysis model,and the interaction between genes and environment was analyzed by crossover analysis combined with a logistic regression analysis model.Results Age above 45 years(x2=7.90,OR=2.28,95％CI:1.28-4.04,P=0.005),smoking(x2=15.27,OR=4.70,95％CI:2.16-10.22,P＜0.001)increased the risk of TB prevalence in the HHC group.Smoking(x2=13.94,OR=3.58,95％CI:1.83-7.01,P＜0.001),living in rural areas(x2=25.05,OR=3.81,95％CI:2.26-6.42,P＜0.001),and poor living room sanitation(x2=15.31,OR=3.20,95％CI:1.79-5.73,P＜0.001)increased the risk of TB prevalence in the HC group.Carriage of TRAF1/C5 rs10818488 AG genotype(co-dominant and hyper-dominant models),GG genotype(co-dominant model),and AG-GG genotype(dominant model)increased the risk of developing TB in the HHC and HC groups.No association between the TNF-αrs 1800629 locus and TB susceptibility was found for the time being.Analyzing gene-environment interactions,there was a synergistic effect of the AG-GG genotype at the TRAF1/C5 rs10818488 locus with smoking between the TB and HHC groups,whereas there was a synergistic effect of the AG-GG genotype at the rs10818488 locus with smoking and poor living room sanitation,and a multiplicative interaction with the place of residence between the TB and HC groups,both of which increased the risk of TB prevelance.Conclusions Gene polymorphisms at the TRAF1/C5 rs10818488 locus may be associated with the risk of TB and interact with smoking,place of residence,and indoor sanitation to jointly influence susceptibility to TB.
万方数据
维普
