首页|南京市社区2型糖尿病患者不同代谢类型肥胖及血糖控制相关性分析

南京市社区2型糖尿病患者不同代谢类型肥胖及血糖控制相关性分析

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目的 探讨南京市社区不同肥胖和代谢类型的2型糖尿病患者分布及血糖控制情况.方法 2021年4-6月在南京市12个区,采取多阶段分层整群随机抽样方法招募2型糖尿病患者,进行问卷调查、体格检查和临床生化指标检测.根据代谢及肥胖状态,将研究对象分为体重正常代谢正常(metabolically healthy and normal weight,MHNW)、体重正常代谢异常(metabolically unhealthy but normal weight,MUHN W)、代谢正常性肥 胖(metabolically healthy obese,MHO)和代谢异常性肥胖(metabolically abnormal obese,MAO).采用logistic回归分析模型进行多因素分析.结果 共纳入研究对象1 389名,平均年龄为(65.14±7.71)岁,男性598名(43.05%).其中MHNW者296名(21.31%),MUHNW 者 319 名(22.97%),MHO 者 109 名(7.85%),MAO 者 665 名(47.87%).年龄越大,发生MUHNW和MAO的比例越高;女性、糖尿病病程≥5年人群中MUHNW比例较高.调查对象空腹血糖(fasting blood glucose,FPG)、糖化血红蛋白(hemoglobinA1c,HbA1c)控制达标率分别为44.92%、48.88%.多因素分析结果显示,MAO者FPG控制未达标率是MHNW者的1.525倍(OR=1.525,95%CI:1.148~2.025,P=0.004);MAO 者 HbA1c 控制未达标率是 MHNW 者的 1.516 倍(OR=1.516,95%CI:1.140~2.016,P=0.004).结论 南京市社区 2 型糖尿病患者 MUHNW 和 MAO较多,MAO的2型糖尿病患者血糖控制较差.应对不同肥胖亚群的2型糖尿病患者进行早期识别和分类干预,能够有效控制血糖,预防糖尿病并发症的发生.
Association between different metabolic types of obesity and glycemic control among community type 2 diabetes patients in Nanjing
Objective To investigate the distribution characteristics and glycemic control of type 2 diabetes patients with different metabolic types and obesity in community in Nanjing.Methods From April to June 2021,multi-stage stratified cluster random sampling method was adopted to recruit type 2 diabetes patients in 12 districts of Nanjing,questionnaire responses,physical examinations and clinical indicators were gathered.According to their metabolic and BMI,the population was divided into metabolically healthy and normal weight(MHNW),metabolically unhealthy but normal weight(MUHNW),metabolically healthy obese(MHO),and metabolically abnormal obese(MAO).Logistic regression was used for multivariate analysis.Results A total of 1 389 subjects were included,with an average age of(65.14±7.71)years old,598 males(43.05%),among which MHNW,MUHNW,MHO,MAO were 21.31%,22.97%,7.85%and 47.87%.The older the age,the higher the incidence of MUHNW and MAO;The proportion of MUHNW in women and patients with diabetes course ≥5 years was higher.The control up to standard rates of fasting blood glucose(FPG)and hemoglobinA1c(HbA1c)among the subjects were 44.92%and 48.88%,respectively.The results of multivariate analysis showed that the incidence of FPG control failure in MAO patients was 1.525 times higher than that in MHNW(OR=1.525,95%CI:1.148-2.025,P=0.004);The incidence of HbAlc control failure in MAO patients was1.516 times higher than that in MHNW patients(OR=1.516,95%CI:1.140-2.016,P=0.004),with statistically significant(P<0.05).Conclusions There are more type 2 diabetes patients with MUHNW and MAO in Nanjing,and the type 2 diabetes patients with MAO have poor glycemic con-trol.Early identification and classified intervention should be carried out for type 2 diabetes patients with different obesity subgroups to effectively control blood glucose,and to prevent and control complications of diabetes.

Type 2 diabetesMetabolic typeObesityGlycemic control

王琛琛、许昊、陈一佳、周海茸、孙倩男、洪忻、周楠

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南京市疾病预防控制中心慢性非传染性疾病防制科,南京 210009

南京医科大学公共卫生学院,南京 211166

2型糖尿病 代谢类型 肥胖 血糖控制

南京市医学科技发展项目

ZKX20045

2024

中华疾病控制杂志
中华预防医学会 安徽医科大学

中华疾病控制杂志

CSTPCD北大核心
影响因子:1.862
ISSN:1674-3679
年,卷(期):2024.28(2)
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