Correlation between TLR2 gene polymorphism and tuberculosis susceptibility in Qinghai Province
Objective To study the relationship between rs3804099 and rs3804100 polymorphisms of Toll-like receptors-2(TLR2)gene and tuberculosis in Qinghai Province.Methods 219 tuberculosis patients from a hospital in Qinghai Province were collected as the case group,and 236 physi-cal examinees at the same time as the control group.The rs3804099 and rs3804100 loci were amplified by polymerase chain reaction(PCR)and genotypes were determined by sequencing.Results rs3804099(x2=4.37,P=0.037)and rs3804100(x2=4.73,P=0.030)polymorphisms in TLR2 were associated with tuberculosis.The model analysis showed,rs3804099(x2=5.23,P=0.022)and rs3804100(x2=7.70,P=0.006)loci were statistically different in the heterozygote model between two groups;while only rs3804100 loci was significantly different in the invisible model(x2=4.92,P=0.027).The rs3804099(x2=4.24,P=0.040)and rs3804100(x2=5.19,P=0.023)polymorphisms of TLR2 gene were correlated with tuberculosis susceptibility in Tibetan population;),but no correlation was found in Han population.Conclusions The rs3804099 and rs3804100 polymorphisms of TLR2 gene are associated with occurence of tuberculosis in Tibetan in Qinghai,and CC genotype may be a risk factor for causing tuberculosis.
万方数据
维普
