Association between fasting blood glucose trajectories and new-onset cardiovascular diseases in the elderly health check-up population in Nanjing
Objective To investigate the association between fasting blood glucose trajectory and the incidence of cardiovascular disease among the elderly population aged 65 years and above in Nanjing.Methods A total of 7 079 participants were included from the Nanjing elderly health checkup cohort who met the inclusion criteria.The trajectory of fasting plasma glucose(FPG)index(FPG was taken as its logarithm to make it obey normal distribution)was constructed by group-based trajectory model(GBTM)over the years from 2018 to 2020.And we followed up the incidence of cardiovascular disease in 2021.A Cox regression model was used to analyze the association between distinct trajectory groups and the incidence of cardiovascular disease.Results The FPG trajectory was finally divided into low-level group(5 635,79.6％),medium-level group(1 201,17.0％)and high-level group(243,3.4％).A total of 70 cases of cardiovascular disease were newly reported during the follow-up period,with the low,medium,and high level groups accounting for 0.83％,1.42％,and 2.47％of the new cases in the group,respectively.The incidence of cardiovascular disease increased with increasing FPG levels(trend x2=8.750,P=0.003),and the difference was statistically significant(x2=9.050,P=0.011).The Cox regression model showed that the risk of cardiovascular disease in the high-level group was 2.96 times higher than that in the low-level group(95％CI:1.27-6.92).Conclusions Long-term high levels of FPG increase the risk of cardiovascular disease in the elderly,so timely intervention and early prevention are warranted.
Elderly populationFasting plasma glucoseTrajectoryCardiovascular diseaseCohort study
NETL
NSTL
万方数据
