摘要
目的 探讨内蒙古地区心血管病高危人群冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)发病的相关危险因素,为制定适合内蒙古地区CHD的防治策略提供科学依据.方法 采用前瞻性队列研究方法,利用多阶段分层整群抽样方法.于2015年12月在内蒙古地区6个盟市开展调查,每年随访1次,直至2021年12月.基线调查包括一般情况、疾病史及治疗史、体格检查和实验室检测,随访调查包括心血管健康状况及临床终点事件收集.采用Cox回归模型分析影响CHD的发病因素.结果 最终纳入37 726名研究对象,多因素Cox回归模型分析表明:增龄(HR＞1.00,P＜0.001)、吸烟(HR=1.20,P＜0.001)、饮酒(HR=1.41,P＜0.001)、超重或肥胖(HR=1.19,P＜0.001)、高血压(HR=1.41,P＜0.001)、糖尿病(HR=1.22,P＜0.001)、血脂异常(HR=2.20,P＜0.001)为CHD发病的危险因素;高教育水平(HR＜1.00,P＜0.001)、非重体力劳动类型(HR＜1.00,P＜0.001)为CHD发病的保护因素.结论 在内蒙古地区,增龄、吸烟、饮酒、血脂异常、高血压、糖尿病、超重或肥胖为CHD发病的危险因素,高教育水平、非重体力劳动为CHD发病的保护因素.
Abstract
Objective To explore the related risk factors of coronary heart disease(CHD)in the population at high risk of cardiovascular disease in Inner Mongolia,and to provide scientific basis for the development of prevention and treatment strategies for CHD in Inner Mongolia.Methods This study was a prospective cohort study,the study population was selected by multi-stage stratified cluster sampling method.A survey was conducted in six cities in Inner Mongolia region from December 2015,and the follow-up survey was conducted once a year until December 2021.The baseline survey included general information,disease and treatment history,physical examination and laboratory tests.The follow-up survey included cardiovascular health status and clinical endpoint events.Cox regression model was used to analyze the risk factors of CHD.Results A total of 37 726 subjects were finally included in this study,multivariate Cox regression analysis showed that:increasing age(HR＞1.00,P＜0.001),smoking(HR=1.20,P＜0.001),drinking(HR=1.41,P＜0.001),overweight or obesity(HR=1.19,P＜0.001),hypertension(HR=1.41,P＜0.001),diabetes(HR=1.22,P＜0.001)were dyslipidemia(HR=2.20,P＜0.001)were risk factors for CHD.In contrast,high education level(HR＜1.00,P＜0.001)and non-heavy physical labor type(HR＜1.00,P＜0.001)were protective factors for CHD.Con-clusions In Inner Mongolia,increasing age,smoking,drinking,dyslipidemia,hypertension,diabetes,overweight or obesity are risk factors for CHD,high education level and non-heavy physical labor type are protective factors for CHD.
基金项目
国家自然科学基金(82160639)
内蒙古自治区高等学校青年科技英才支持计划(NJYT22008)
内蒙古医科大学心血管病分子流行病学及防治研究科技创新团队项目(YKD2022TD015)
内蒙古医科大学学科建设项目(YKD2022XK012)
NETL
NSTL
万方数据