A cross-sectional study of Helicobacter pylori infection and metabolic syndrome
Objective To understand the cross-sectional association of Helicobacter pylori(H.pylori)infection with metabolic syndrome(MetS)and its four components among residents with health checkups in Beijing.Methods Participants aged 18 or older who attended health checkups at Beijing MJ Health Screening Center during 2009-2020 were included.The H.pylori infection status was identified by the 13C-urea breath test.The diagnoses of MetS and its four components(abdominal obesity,hyperglyce-mia,high blood pressure,and dyslipidemia)were defined according to the Joint Committee for Develo-ping Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.Multivariate logistic re-gression was performed to estimate the OR and 95%CI.Results Among the 31 369 participants,58.7%were men,and the mean age was(45.3±11.6)years.The H.pylori-positive rate was 35.7%,and the prevalence rate of MetS was 25.6%.The overall prevalence of MetS in males was higher than in females.After adjusting for potential confounders,participants infected with H.pylori had elevated risks of MetS(OR=1.18,95%CI:1.11-1.25,P<0.001)and its four components.The ORs for abdominal obesity(OR=1.18,95%CI:1.11-1.24,P<0.001)and dyslipidemia(OR=1.14,95%CI:1.06-1.22,P<0.001)were higher.The association for dyslipidemia was stronger among females than males(P=0.003).Conclusions H.pylori infection is remarkably correlated with increased risks of MetS and its components after adjusting for potential confounders.
Helicobacter pyloriMetabolic syndromeCross-sectional study