A cohort study on the relationship between women's pre-pregnancy abnormal alanine aminotrans-ferase,advanced age delivery and preterm low birth weight of newborns
Objective To explore the relationship between women's pre-pregnancy abnormal alanine aminotransferase(ALT),advanced age delivery and preterm low birth weight of newborns.Methods A historical cohort study was conducted to select women of childbearing age who participated in free pre-marital health check-ups and pre-pregnancy eugenic health check-ups in Dongguan from January 2015 to September 2020.The basic information and relevant examination results of the subjects were obtained,and their pregnancy outcomes were followed up.Multivariate logistic regressions were used to analyze the effects of women's pre-pregnancy abnormal ALT and advanced age delivery on preterm low birth weight of newborns.The stability of the results was tested by subgroup analysis and sensitivity analysis.Results A total of 23 620 subjects were included in the analysis.The incidence of preterm low birth weight of newborns was 2.90％.Multivariate logistic regression analysis showed that after adjusting covariates,women's pre-pregnancy abnormal ALT could increased the risk of preterm low birth weight(RR=1.527,95％CI:1.133-2.016,P=0.004).Delivery at an advanced age increased the risk of preterm low birth weight(RR=1.257,95％CI:1.006-1.562,P=0.042).Effect sizes were similar in subgroups of infant gender,mother's delivery history and mode of delivery,and there was no statistically significant difference in heterogeneity between groups(all P＞0.05).After excluding people with abnormal blood glucose(GLU)before pregnancy and hepatitis B surface antigen(HBsAg)positive before pregnancy,the effects remained.Conclusions Women's pre-pregnancy abnormal ALT and advanced age delivery are associated with preterm low birth weight.
Alanine aminotransferaseAdvanced ageDeliveryPreterm birthBirth weightCohort study
NETL
NSTL
万方数据
