Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly
Objective To analyze the association between plasma levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)and mild cognitive impairment(MCI)in elderly individuals aged 65 years and older in Guangdong.Methods A total of 48 MCI elderly patients who visited a community health service center in Guangdong were selected as the case group,while 96 non-MCI individuals served as controls.Logistic regression models were used to analyze the association between plasma levels of IL-6 and TNF-α and MCI.Receiver operating characteristic(ROC)curves were plotted to evaluate the diag-nostic value of plasma levels of IL-6 and TNF-α for MCI.Results A total of 144 elderly individuals were enrolled,including 48 MCI patients and 63 males(43.8％).The results of the multivariate logistic re-gression models showed that increased plasma levels of IL-6 and TNF-α could lead to a higher risk of MCI.Specifically,the risk of MCI increased by 53％and 51％for each standard deviation increase in plasma levels of IL-6 and TNF-α,respectively(OR=1.53,95％CI:1.02-2.29,P=0.040;OR=1.51,95％CI:1.04-2.20,P=0.029).The areas under the ROC curves for IL-6 and TNF-α were 0.60 and 0.64,respectively.Conclusions The increased risk of MCI in individuals aged 65 years and older may be associated with elevated plasma levels of IL-6 and TNF-α.
ElderlyMild cognitive impairmentInterleukin-6Tumor necrosis factor-αCase-control study
NETL
NSTL
万方数据
