老年人血浆IL-6、TNF-α水平与轻度认知功能障碍的关联
Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly
吴茵如 1钟逸诗 1高健 1陈沛良 1由芳菲 1宋玮琦 1毛琛1
作者信息
- 1. 南方医科大学公共卫生学院流行病学系,广州 510515
- 折叠
摘要
目的 分析广东老年人(≥65岁)血浆白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平与轻度认知功能障碍(mild cognitive impairment,MCI)的关联.方法 选取广东某社区卫生服务中心就诊的48例老年MCI患者作为病例组,96例无MCI的老年人作为对照组.采用logistic回归分析血浆IL-6、TNF-α水平与MCI的关联.绘制受试者工作特征(receiver operating characteristic,ROC)曲线评估血浆IL-6、TNF-α水平对MCI的诊断价值.结果 共纳入144名老年人,其中48名MCI患者,63名男性(43.8％).多因素logistic回归分析结果显示,血浆IL-6、TNF-α水平升高可使MCI患病风险增加,血浆IL-6、TNF-α水平每增高1个s,MCI 患病风险分别增加 53％和 51％(OR=1.53,95％CI:1.02～2.29,P=0.040;OR=1.51,95％CI:1.04～2.20,P=0.029).血浆 IL-6、TNF-α 的 ROC 曲线下面积分别为0.60、0.64.结论 血浆IL-6和TNF-α水平升高可能与≥65岁老年人MCI患病风险的增加有关.
Abstract
Objective To analyze the association between plasma levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)and mild cognitive impairment(MCI)in elderly individuals aged 65 years and older in Guangdong.Methods A total of 48 MCI elderly patients who visited a community health service center in Guangdong were selected as the case group,while 96 non-MCI individuals served as controls.Logistic regression models were used to analyze the association between plasma levels of IL-6 and TNF-α and MCI.Receiver operating characteristic(ROC)curves were plotted to evaluate the diag-nostic value of plasma levels of IL-6 and TNF-α for MCI.Results A total of 144 elderly individuals were enrolled,including 48 MCI patients and 63 males(43.8％).The results of the multivariate logistic re-gression models showed that increased plasma levels of IL-6 and TNF-α could lead to a higher risk of MCI.Specifically,the risk of MCI increased by 53％and 51％for each standard deviation increase in plasma levels of IL-6 and TNF-α,respectively(OR=1.53,95％CI:1.02-2.29,P=0.040;OR=1.51,95％CI:1.04-2.20,P=0.029).The areas under the ROC curves for IL-6 and TNF-α were 0.60 and 0.64,respectively.Conclusions The increased risk of MCI in individuals aged 65 years and older may be associated with elevated plasma levels of IL-6 and TNF-α.
关键词
老年人/轻度认知功能障碍/白细胞介素-6/肿瘤坏死因子-α/病例对照研究Key words
Elderly/Mild cognitive impairment/Interleukin-6/Tumor necrosis factor-α/Case-control study引用本文复制引用
出版年
2024
NETL
NSTL
万方数据