Association between short-term air pollution exposure and placental abruption:a nested case-control study
Objective To explore the association between short-term air pollution exposure and acute onset of placental abruption.Methods This study is a nested case-control study nested in the large birth cohort of Chongqing.A total of 798 pregnant women with new placental abruption from July 31,2018 to July 31,2022 were selected as the case group.A control group of 3,192 women without abruptio placentae was matched at a ratio of 1∶4 according to age,gestational age,gravidity,parity,and delivery date.The data set of six air pollutants(PM10,PM2.5,NO2,CO,O3,SO2)and meteorological factors was estimated by machine learning algorithm and matched with the longitude and latitude of each subject's residence address.A distributed lag non-linear models based on conditional Logistic regression was constructed to explore the exposure-response relationship between short-term air pollutants exposure and placental abruption,controlling the effects of temperature,relative humidity,wind speed,atmospheric pressures and NDVI,as well as the age,gestation week,gravidity(first pregnancy/non-first pregnancy),pravity(first birth/non-first birth),delivery season(cool/warm seasons),whether experienced the epidemic(Yes/No),and residential address(urban/countryside).Results The results of single pollutant model showed that NO2 was significantly associated with the increased risk of placental abruption within 4 to 7 days of cumulative exposure,and the odds ratio for each increase in IQR of NO2 was 1.38(95％CI:1.11-1.73,P＜0.001)to to 1.54(95％CI:1.18-2.02,P＜0.001).The overall dose-response curve showed that the risk of placental abruption increased with the increase of NO2 concentration,and the exposure-response curve was approximately linear.There was no statistically significant association between short-term exposure to other pollutants and the risk of placental abruption.Conclusions Short-term exposure to NO2 is associated with an increased risk of acute onset of placental abruption,which may be an influencing factor of placental abruption,and further studies are necessary to verify this.
Air pollutantsPlacental abruptionDistributed lag non-linear model
NETL
NSTL
万方数据
