目的 评价重庆市孕妇与新生儿体内有机磷阻燃剂负荷水平、组成分布及其相关性.方法 基于重庆市孕前生殖健康与出生结局队列研究.纳入2020年11月-2021年11月在重庆市妇幼保健院分娩的健康孕妇-新生儿221对.采用液相色谱/质谱法测定血清中8种有机磷阻燃剂代谢产物(metabolites of organophosphate flame retardants,mOPFRs)的含量.Spearman 秩相关分析孕妇外周静脉血与新生儿脐带血中8种mOPFRs的相关性.结果 孕妇外周静脉血中总mOPFRs检出率为84.6％,各种mOPFRs单体检出率为12.7％～76.9％;新生儿脐带血中总mOPFRs检出率为93.2％,各mOPFRs单体检出率为1.8％～91.0％.孕妇外周静脉血中的磷酸二邻甲苯酯&磷酸二对甲苯酯、二(2-乙基己基)磷酸酯分别与新生儿脐带血中该单体呈正相关(r=0.29和0.22,均P＜0.05).结论 重庆市孕妇外周静脉血及新生儿脐带血中可以检测出多种mOPFRs,并且孕妇与新生儿体内的mOPFRs水平存在相关关系.
Study on the load level,composition distribution and correlation of organophosphorus flame retardants in pregnant women and newborns in Chongqing
Objective To evaluate the organophosphate flame retardants(OPFRs)loads of pregnant women and newborns in Chongqing and its relationship,components and correlation.Methods Date were drawn from The Preconception Reproductive Health and Birth Outcome Cohort(PREBIC),and a total of 221 healthy pregnant women-newborns pairs who delivered in Chongqing Maternal and Child Health Hospital from November 2020-November 2021 were included in the final analysis.The levels of 8 mOPFRs in serum were detected by liquid chromatography/mass spectrometry.The Spearman rank correlation analysis was used to analyze the association of 8 mOPFRs exposure levels in peripheral venous blood of pregnant women and umbilical cord blood of newborns.Results The detection rate of total mOPFRs(∑ mOPFRs)in peripheral venous blood of pregnant women was 84.6％,and the detection rate of each mOPFRs ranged from 12.7％to 76.9％;the detection rate of∑mOPFRs in umbilical cord blood of newborns was 93.2％,and the detection rate of each mOPFRs ranged from 1.8％to 91.0％.di-o-tolyl phosphate(DoCP)& di-o-tolyl phosphate(DpCP)and bis(2-ethylhexyl)phthalate(BEHP)in peripheral venous blood of pregnant women were correlated with the concentrations in umbilical cord blood of newborns(r=0.29 and 0.22,P＜0.05).Conclusions A variety of mOPFRs were detected in peripheral venous blood of pregnant women and umbilical cord blood of newborns in Chongqing,and there was a correlation between the levels of mOPFRs in pregnant women and newborns.
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