The causal association between ischemic stroke and the risk of membranous nephropathy based on two-sample Mendelian randomization
Objective To investigate the causal relationship between ischemic stroke and incidence of membranous nephropathy using a Two-sample Mendelian randomization(MR)method.Methods Single nucleotide polymorphisms(SNPs),which were independent of each other and closely associated with ischemic stroke were identified from a Genome-Wide Association analysis.The identified SNPs were used as instrumental variables.Odds ratios were obtained from the MR analyses on the causal association between ischemic stroke and membranous nephropathy using the inverse variance weighted analysis,weighted median method,and MR-Egger method.Results A total of 17 SNPs that were associated with ischemic stroke were identified in this study.The inverse variance weighted analysis showed that ischemic stroke was associated with higher risk of membranous nephropathy(OR=1.61,95％CI:1.11-2.33,P=0.01).Results of the sensitivity analysis were consistent with those of the main analysis,confirming the robustness of this study.No heterogeneity among SNPs was observed in this study.Conclusions From a genetic perspective,the present study suggested an association between ischaemic stroke and elevated risk of membranous nephropathy.Strengthening screening and prevention of membranous nephropathy among patients diagnosed with ischemic stroke is of great clinical and public health significance.
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