Application of microfluidic chips in the study of pneumoconiosis
Pneumoconiosis is a serious occupational disease that threats human health in physical and mental.Studying its mechanism is of great significance in the prevention,diagnosis,and treatment of pneumoconiosis.However,there are many technical difficulties in the traditional in-vivo and in-vitro research methods,which are unable to reproduce the three-dimensional lung tissue and the physical and biological microenvironment of the lung in-vivo,and it is difficult to conduct real-time dynamic observation of the physiological and biochemical processes,which restricts the research on the pathological mechanism of pneumoconiosis.Microfluidic chips,with their ability to manipulate cells,particles and solutions in time and space,provide new ideas for simulating the state of the lungs and reconstructing their physical and biological microenvironment.Starting from the interaction between dust particles and the lungs,this article reviews the deposition characteristics of dust particles in the lungs,the physiological and biochemical changes caused by dust particles on the lungs,and the research progress in the interaction between dust particles and pneumoconiosis using microfluidic chips.
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