Objective To analyze the epidemiological and spatial-temporal distribution of pertussis in Yunnan from 2005 to 2022,and to provide evidence for improving prevention and control strategy.Methods Pertussis epidemic report and surveillance data in Yunnan Province from 2005 to 2022 were analyzed through the China Disease Prevention and Control Information System.Descriptive epidemiological methods were used to describe the disease distribution characteristics.Cluster analysis was used to analyze inter-regional incidence.Joinpoint regression model was used to analyze the trend of incidence.Results From 2005 to 2022,2 115 pertussis cases were reported in Yunnan,with an average annual incidence rate of 0.253 4 per 100 000.The cases were mostly in 0-＜5 years group(1 691,79.95％),the highest average annual incidence rate was in the 0-＜1 years group(11.440 4 per 100 000),adult cases had reports annually since 2018.The cases were reported every month,and in the third and second quarters the average incidence rate was higher,which was 0.073 8 per 100 000 and 0.073 3 per 100 000.The average annual incidence rate showed an upward trend in 2005-2022,with an average annual percentage change(AAPC)of 9.93％.It showed a downward trend in 2005-2014,with an annual percentage change(APC)of-11.82％,and a rapid upward trend in 2015-2022,with APC of 50.62％.The highest endemic area was Yuxi,and the areas with obvious increases was Yuxi,Zhaotong,and Xishuangbanna.Conclusions The average annual incidence of pertussis in Yunnan Province is on the rise in general and increased rapidly after 2015.Pertussis still mainly happens infants and young chil-dren aged 0-＜5 years,the second and third quarter are the high incidence season.The incidence rates and growth trends are different between every area.We suggest enhancing diagnosis and surveillance capabilities and strengthening epidemic prevention and control in key regions,seasons and populations.
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