首页|相邻日间温度变化对缺血性脑卒中的影响

相邻日间温度变化对缺血性脑卒中的影响

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目的 评估相邻日间温度变化(temperature changes between neighboring days,TCN)对缺血性脑卒中门诊就诊风险的影响.方法 利用合肥市一所大型三甲医院缺血性脑卒中门诊就诊数据进行分析,采用分布滞后非线性模型结合泊松广义线性回归模型分析TCN与缺血性脑卒中门诊就诊人次之间的关系,对相关环境因素进行校正,并对不同性别和年龄的人群进行了分层分析.结果 合肥市2014-2018年共有32 560例缺血性脑卒中患者,其中男性占57.2%,≥65岁的人群占49.7%,平均每日就诊人数为17.8人次.暴露-反应关系曲线显示TCN与缺血性脑卒中门诊就诊量相关.以TCN无变化(0)为参考,极端负TCN(P5,-3.9 ℃)的相对风险在累计滞后7 d达到最大(RR=1.796,95%CI:1.150~2.805),而极端正TCN(P95,3.0℃)的相对风险在累计滞后6 d达到最大(RR=0.686,95%CI:0.499~0.945).亚组分析显示,男性和≥65岁缺血性脑卒中患者更易受负TCN的影响.结论 合肥市TCN与缺血性脑卒中呈非线性关系;负TCN增加缺血性脑卒中患者的门诊就诊风险,当气温骤降时注意缺血性脑卒中的发生;正TCN降低缺血性脑卒中患者的门诊就诊风险,当气温升高时需要注意防暑降温,避免高温引起的其他健康问题.
Impact of temperature changes between neighboring days on ischemic stroke
Objective To assess the effect of temperature changes between neighboring days on the risk of ischemic stroke outpatient visits.Methods A distributional lag nonlinear model combined with a Poisson generalised linear regression model was used to analyse the relationship between temperature changes between neighboring days and ischemic stroke outpatient visits at a large tertiary hospital in Hefei city,with corrections for relevant environmental factors and stratified by different gender and age groups.Results In this study,there were 32 560 ischemic stroke patients,with an average of 17.8 ischemic stroke visits per day.Exposure relationship curves show significant association between TCN and ischemic stroke outpatient visits.The relative risk over 0-7days Reached 1.796(95%CI:1.150-2.805)for extreme negative temperature changes between neighboring days(5th percentile),whereas the relative risk of extreme positive temperature changes between neighboring days(95th percentile)was 0.686(95%CI:0.499-0.945)and maximized at a cumulative lag of 6 days.Subgroup studies revealed that men and ischemic stroke patients over the age of 65 were more vulnerable to negative temperature changes between neighboring days.Conclusions Temperature changes between neighboring days and is-chemic stroke are nonlinearly related in Hefei;with negative temperature changes between neighboring days increases the likelihood for ischemic stroke patients,watch for ischemic stroke when temperature drops suddenly;and positive temperature changes between neighboring days decreases the risk of ischemic stroke patients,who require protection from heat and other health concerns induced by rising temperature.

Ischemic strokeTemperature changes between neighboring daysDistributed lag nonlinear modelTime-series study

王影、胡皖琴、孙浩翔、杨吉丹、康芮含、胡华青

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安徽医科大学第一附属医院全科医学科,合肥 230022

安徽医科大学公共卫生学院,合肥 230022

深圳市宝安区人民医院全科医学科,深圳 518101

安徽医科大学第一附属医院物资设备处,合肥 230022

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缺血性脑卒中 相邻日间温度变化 分布滞后非线性模型 时间序列研究

国家重点研发计划

2020YFC2006506

2024

中华疾病控制杂志
中华预防医学会 安徽医科大学

中华疾病控制杂志

CSTPCD北大核心
影响因子:1.862
ISSN:1674-3679
年,卷(期):2024.28(6)
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