A cohort study of the effect of cumulative exposure to LDL-C on cardiovascular disease among the uyghur population in southern Xinjiang
Objective To explore the effect of cumulative exposure to low-density lipoprotein cholesterol(LDL-C)on cardiovascular disease(CVD)among the Uyghur population in southern Xinjiang.Methods We recruited 2 950 Uyghurs from the 51st Corps of the 3rd division of Xinjiang Production and Construction Corps,who had measured LDL-C at least three times during the 2016-2022 survey period,and two adjacent measurement intervals≥2 years.Cumulative LDL-C(cumLDL-C)exposure was calculated by the weighted sum of LDL-C measured value for each time interval(value × time).Participants were grouped according to the cumLDL-C tertiles.The Log-rank test was used to compare the differences in the cumulative incidence of CVD among the groups.Cox proportional hazard re-gression models were used to estimate the effect of cumLDL-C on CVD.Results During the follow-up period,322(10.92％)CVD events occurred.The cumulative incidence of CVD from the first to third tertile group of cumLDL-C was 7.12％,11.08％,and 14.55％,respectively(x2=27.440,P＜0.001).Cox proportional hazards model showed that after adjusting for multiple confounders,the risk of CVD in the third tertile of cumLDL-C compared with the first tertile was 1.51 times higher(HR=1.51,95％CI:1.12-2.06).Each standard deviation increase in cumLDL-C was associated with a 14％increased risk of CVD(HR=1.14,95％CI:1.01-1.28).Conclusions In the Uyghur population in southern Xinjiang,cumulative exposure to high LDL-C is an independent risk factor for CVD,and maintaining low LDL-C levels for a long period of time can help reduce the risk of CVD in this population.
Low-density lipoprotein cholesterolCumulative exposureCardiovascular diseaseCohort study
NETL
NSTL
万方数据
