首页|铅暴露对职业性暴露人群甲状腺激素水平影响的Meta分析

铅暴露对职业性暴露人群甲状腺激素水平影响的Meta分析

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目的 应用Meta分析探讨职业性铅暴露人群血铅水平与各类甲状腺激素(thyroid hormones,TH)水平的关系.方法 通过计算机检索中英文数据库(中国知网、万方数据知识服务平台、维普中文科技期刊数据库、PubMed、Web of Science),收集从建库至2022年10月国内外公开发表的有关铅暴露与TH水平的横断面研究,应用Stata 14.0软件进行Meta分析.结果 共纳入14篇文献进行分析.Meta分析结果显示,与一般人群比较,职业性铅暴露人群中,血铅水平较高,促甲状腺激素(thyroid stimulating hormone,TSH)、甲状腺素(thyroxine,T4)、三碘甲状腺原氨酸(triiodothyronine,T3)、游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)5种TH的平均浓度差异均无统计学意义(均P>0.05);暴露组血铅水平高于200 μg/L时,TSH水平升高,与对照组TSH的平均浓度差异有统计学意义(P<0.05).结论 职业性铅暴露人群中高血铅水平与TSH水平升高相关.
Effect of lead exposure on thyroid hormone levels in occupationally exposed populations:a Meta-analysis
Objective Meta-analysis was used to explore the relationship between blood lead levels and thyroid hormone(TH)levels in people with occupational lead exposure.Methods Meta-analysis was performed using Stata14.0.Chinese and English databases,including CNKI,Wanfang Data Knowledge Service Platform,Chinese Science and Technology Journal Database,PubMed,Web of Science were searched.Cross-sectional studies on the relationship between lead exposure and thyroid hormone levels published from the databases establishment to October 2022 were collected.Results A total of 14 literatures were included for analysis.The results showed that compared with control popula-tion,the blood lead level was higher in people with occupational lead exposure.There was no statistical significance(all P>0.05)in the average concentrations of thyroid stimulating hormone(TSH),thyroxine(T4),triiodothyronine(T3),free triiodothyronine(FT4)and free thyroxine(FT4)between the two groups.When the blood lead level in the exposed group was higher than 200 μg/L,the TSH level increased,and the difference between the exposed group and the control group was statistically significant(P<0.05).Conclusions High blood lead level is associated with elevated TSH level in people with occupational lead exposure.

OccupationalLead exposureBlood lead levelThyroid hormoneThyroid stimulating hormoneCross-sectional studyMeta-analysis

彭晓琨、韩竣宇、景楠、杨乾磊、张恒东、安艳

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苏州大学医学院公共卫生学院毒理学系,江苏省老年病预防与转化医学重点实验室,苏州 215123

江苏省疾病预防控制中心职业病防治所,南京 210009

江苏省预防医学会,南京 210009

职业性 铅暴露 血铅水平 甲状腺激素 促甲状腺激素 横断面研究 Meta分析

国家自然科学基金国家自然科学基金国家自然科学基金江苏省卫生健康委科研项目江苏省医学重点学科

818726468181154003481573173ZD2021024ZDXK202249

2024

中华疾病控制杂志
中华预防医学会 安徽医科大学

中华疾病控制杂志

CSTPCD北大核心
影响因子:1.862
ISSN:1674-3679
年,卷(期):2024.28(7)