A bidirectional two-sample mendelian randomization analysis of the relationship between mild to moderate depression and the risk of knee osteoarthritis
Objective To utilize a bidirectional Mendelian randomization(MR)analysis to examine the causal link between mild-to-moderate depression and knee osteoarthritis(KOA),offering novel perspectives for the prevention,management,and prognostic evaluation of KOA.Methods Genome-wide association study(GWAS)data were utilized,genetic loci closely associated with mild-to-moderate depression and KOA were selected as instrumental variables.The inverse variance weighted(IVW)was employed as the primary analytical approach to assess causal effects,supplemented by methods such as weighted median(WM),simple median(SM),weighted mode,and MR-Egger regres-sion for two-sample MR analysis.The causal relationship between mild-to-moderate depression and KOA was evaluated using OR,with tests for heterogeneity,genetic pleiotropy,and sensitivity analysis to assess the stability and reliability of the results.Results MR analysis indicated that patients with mild-to-moderate depression had a 1.64-fold increased risk of KOA compared to the healthy population(OR=1.64,95％CI:1.34-2.02;P＜0.001).External validation confirmed that mild-to-moderate depression indeed increases the risk of KOA.Conclusions A potential causal association may exist between mild-to-moderate depression and KOA,with mild-to-moderate depression possibly serving as a risk factor for KOA.
万方数据
维普
