Association between dietary inflammation index and serum C reactive protein level:a Meta-analysis
Objective To systematically evaluate the association between the dietary inflammato-ry index(DII)and serum C-reactive protein(CRP)levels.Methods A search of the PubMed,Web of Science,and EMBASE databases was conducted to collect studies examining the association between the DII and CRP.The search period extended from the inception of each database until October 1,2023.Two independent researchers performed the literature screening,data extraction,and quality assessment.Sta-tistical analyses were conducted using R software version 4.2.2,and subgroup analyses and Meta-regres-sion were utilized to explore the sources of heterogeneity among studies.Results A total of 20 studies were included,comprising 15 cross-sectional studies,1 case-control study,3 cohort studies,and 1 ran-domized controlled trial,with a cumulative total of 59 953 participants.The Meta-analysis indicated a sig-nificant association between the DII and serum CRP levels(OR=1.205,95％CI:1.101～1.319).After conducting subgroup analyses based on study design,age distribution,sample size,DII calculation meth-ods,and dietary assessment techniques,the I2 statistic was reduced(P＞0.1).Conclusions Current evidence suggests that the DII may be associated with serum CRP levels.Differences in study design,age distribution,sample size,DII calculation methods,and dietary assessment techniques may be the primary factors contributing to the heterogeneity observed among the studies.
NETL
NSTL
万方数据
