A prospective cohort study on the association of maternal perinatal cigarette smoking,alcohol consumption and their interactions with risk of neonatal low birth weight
Objective To assess the effects of maternal cigarette smoking and alcohol consump-tion and their interactions during periconceptional pregnancy on the risk of low birth weight(LBW)in newborns.Methods Pregnant women attending their initial early prenatal care in Hunan Province were recruited to establish a cohort.Information was collected through questionnaires and medical records,with telephone follow-ups to monitor pregnancy outcomes including LBW.The logistic regression analysis was applied to assess the associations of maternal periconceptional cigarette smoking,alcohol consumption,and their interactions with the risk of LBW.Meanwhile,stratified analysis was conducted to evaluate the stability of the associations.Results A total of 34 104 singleton pregnancies and newborns were included in this study.Among these newborns,3 020 cases were diagnosed with LBW,with an incidence of 8.9％(95％CI:8.6％-9.2％).The multivariate logistic regression analysis showed that maternal active smoking(OR=1.428,95％CI:1.147-1.777),passive smoking(OR=1.128,95％CI:1.031-1.235),and alcohol consumption(OR=2.297,95％CI:1.949-2.706)during periconceptional pregnancy were significantly associated with risk of LBW(all P＜0.05).Additionally,the interaction analysis revealed an antagonistic effect between active smoking and alcohol consumption(OR=0.117,95％CI:0.049-0.278).Conclusions Maternal periconceptional active smoking,passive smoking,alcohol consumption and their interactions are significantly associated with neonatal LBW,highlighting the importance of maintaining healthy behaviors during pregnancy to prevent LBW.
Low birth weightCigarette smokingAlcohol consumptionInteractionProspective cohort study
万方数据
维普
