目的 了解2010-2020年江苏省育龄人群乙型肝炎病毒(hepatitis B virus,HBV)血清学检测结果,为科学防控HBV感染提供参考.方法 收集2010-2020年参加国家免费孕前优生健康检查项目的1 061 396例(530 698对)育龄人群HBV血清学检测结果,分析江苏省育龄人群HBV感染现状和影响因素.结果 2010-2020年江苏省育龄人群乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)总阳性率为 4.49％,乙型肝炎表面抗体(hepatitis B surface antibody,HBsAb)总阳性率为35.82％,HBsAg阳性率和HBsAb阳性率均呈下降趋势(HBsAg:趋势x2=542.665,P＜0.001;HBsAb:趋势x2=727.147,P＜0.001).不同检测年份、性别、年龄、文化程度和职业的育龄人群HBsAg阳性率、HBsAb阳性率差异均有统计学意义(均P＜0.001),不同民族、疫苗接种情况、户口的育龄人群HBsAb阳性率差异均有统计学意义(均P＜0.001),但HBsAg阳性率差异无统计学意义(P＞0.05).育龄夫妇中,单独一方HBsAg阳性的占8.33％,其中50.67％的配偶HBsAb为阴性.结论 江苏省育龄人群HBV感染率处于全国中等水平,2010-2020年育龄人群HBsAg阳性率逐渐降低.HBsAb阳性率偏低,大部分育龄人群属于HBV易感人群,尤其是在单独一方HBsAg阳性的家庭中,＞50％的配偶HBsAb为阴性,建议及时进行乙型肝炎疫苗接种、提高HBsAb保护率.HBsAg阳性率还与性别、年龄、文化程度、职业等因素相关,需制定针对性的防控措施,进一步巩固和加强乙型病毒性肝炎防控效果.
Serological testing results of hepatitis B virus among the population of childbearing age in Jiangsu Province from 2010 to 2020
Objective To investigate the serological testing results of HBV among the population of childbearing age in Jiangsu Province from 2010 to 2020,and to provide reference for scientific preven-tion and control of HBV infection.Methods Serological testing results of HBV were collected from 1 061396 cases(530 698 pairs)of childbearing age population who participated in the national free pre-pregnancy health examination program from 2010 to 2020,and the HBV infection status and influencing factors were analyzed in Jiangsu Province.Results From 2010 to 2020,the total positive rate of HBsAg and HBsAb was 4.49％and 35.82％respectively in Jiangsu Province,and the positive rate of HBsAg and HBsAb showed an downward trend(HBsAg:trend x2=542.665,P＜0.001;HBsAb:trend x2=727.147,P＜0.001).The positive rate of HBsAg and HBsAb were statistically significant in different testing years,gender,age groups,educational levels and occupations(all P＜0.001).The positive rate of HBsAb was also statistically significant in different ethnic groups,hepatitis B vaccination status and registered permanent residence(all P＜0.001),but there was no significant difference in the positive rate of HBsAg(P＞0.05).Among the couples of childbearing age,8.33％of husbands or wives whose HBsAg test results was positive alone,while 50.67％of their spouses tested negative for HBsAb.Conclusions The overall HBV infection rate among the population of childbearing age in Jiangsu Province is at the medium level,and the positive rate of HBsAg decreased gradually from 2010 to 2020.However,the overall positive rate of HBsAb is still low,and most people of the childbearing age are susceptible to HBV,especially in the families whose husbands or wives tested positive for HBsAg alone.Cosidering over half of their spouses tested negative for HBsAb,emphasizing the importance of timely hepatitis B vaccina-tion and improving the protection rate of HBsAb.The positive rate of HBsAg is also related to different gender,age groups,educational level,occupation and other factors,it is necessary to formulate targeted prevention and control measures to further consolidate and strengthen the prevention and control effect of HBV.
Hepatitis B virusHepatitis B surface antigenHepatitis B surface antibodyPre-pregnancy health examination
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