Association of autonomic nervous system function with depressive symptoms in HIV-positive individuals
Objective To analyze the association of depressive symptoms with autonomic nervous system(ANS)function among human immunodeficiency virus(HIV)positive individuals.Methods This was a cross-sectional study between January and December 2023.HIV-positive individuals were recruited using convenient sampling.The composite autonomic symptom scale 31 composite autonomic symptom score(COMPASS-31)questionnaire was used to evaluate the autonomic nervous function symptom.A linear regression model was used to analyze the associated factors of COMPASS-31 scores among HIV-positive individuals,with adjustment for potential confounding factors,and stratification by different age groups.Results In total,311 HIV-positive individuals were included.The average age was(42.0±14.0)years.The average COMPASS-31 total score was 8.1(3.9,14.8)points.The total score,vasomotor scores and gastrointestinal scores were higher,while Bladder scores were comparatively lower among HIV-positive individuals under 45 years.Multivariable linear regression results showed that age,waist-to-hip ratio(WHR)and maximum hand grip were negatively correlated with COMPASS-31 score,while insomnia symptoms and sleep duration of less than 6 hours were positively correlated with COMPASS-31 score.After further adjustment of depressive symptom score(β=-0.07,95％CI:-0.14-0.00,P=0.045;β=-2.84,95％CI:-4.73--0.95,P=0.004;β=-0.14,95％CI:-0.25--0.02,P=0.020),age,high WHR and maximum hand grip were negatively correlated with COMPASS-31 score(β=0.070,95％CI:0.42-0.97,P＜0.001),while depressive symptom score were positively correlated with COMPASS-31 score(β=-3.56,95％CI:-6.07--1.05,P=0.006;β=-0.20,95％CI:-0.36--0.04,P=0.014).Further stratified analysis by age groups revealed that among HIV-positive individuals under 45 years old,higher WHR and maximum hand grip were negatively correlated with COMPASS-31 scores.Additionally,positive correlations between COMPASS-31 scores and CD4 cell count＞500 cells/µL,as well as depressive symptom scores,were observed exclusively in this young age group(β=3.51,95％CI:0.89-6.14,P=0.010;β=0.79,95％CI:0.44-1.14,P＜0.001).Conclusions Depression can aggravate the severity of autonomic nervous dysfunction symptoms in HIV-positive individuals,appropriate health guidance should be provided in response.
Human immunodeficiency virusDepressive symptomsAutonomic nervous system function
万方数据
维普
