Analysis on the survival status and influencing factors of HIV/AIDS:a retrospective cohort study from 2000 to 2021 in Nanjing,China
Objective To investigate the survival status and influencing factors of human immu-nodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)(HIV/AIDS)patients in Nan-jing.Methods The retrospective cohort study of newly diagnosed HIV was conducted in Nanjing and used citywide data from the HIV/AIDS Comprehensive Information Management System from 2000 to 2021.Kaplan-Meier and cox proportional hazard regression method were used to draw the survival curve and analyze the factors associated with AIDS-related deaths,respectively.Results Among 5 903 HIV/AIDS cases,the AIDS-related mortality was 0.93 per 100 person-years and the cumulative survival rates at 1,5,10,and 22 years were 97.2％,95.3％,92.9％,and 90.0％,respectively.Multivariate analy-sis revealed that compared to untreated HIV/AIDS,the earlier the initiation of antiretroviral therapy(ART)after diagnosis,the lower the AIDS-related death risk.The HIV/AIDS with a baseline viral load(VL)≥80 000 copies/mL had 6.54 times higher AIDS-related death risk than those with VL＜20 000 copies/mL.Compared to the first CD4 count before ART＜200 cells/μL,the higher the CD4 level,the lower the AIDS related death risk.ART was more effective in prolonging survival time among those with first CD4 count before ART＜200 cells/μL.Conclusions The AIDS-related mortality of HIV/AIDS is low in Nanjing.Early diagnosis,low baseline VL and rapid initiation of ART are protective factors for AIDS-related death.Therefore,on the basis of promoting the early diagnosis of HIV,we should strengthen the baseline monitoring of VL,optimize the follow-up management process to promote rapid ART,so as to further reduce the risk of AIDS-related death.
Human immunodeficiency virusAcquired immune deficiency syndromeAntiretro-viral therapySurvival timeMortalityRisk factor
万方数据
维普
