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多杀性巴氏杆菌耐药机制研究进展

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多杀性巴氏杆菌属于革兰氏阴性杆菌,能感染多种宿主,可引起禽霍乱、猪萎缩性鼻炎、猪肺疫、牛羊及兔的出血性败血症.随着抗生素的广泛使用,该病原菌的耐药性也在逐年增加.近几年的研究中更是经常发现部分病原菌会对β-内酰胺类、大环内酯类、喹诺酮类、四环素类、氯霉素类、磺胺类抗生素产生较强的耐药性.本文就多杀性巴氏杆菌对6类抗生素的药物敏感性及耐药机制进行了总结,为新药的研究以及新型疗法的建立提供理论依据.
Progress of Drug Resistance Mechanisms of Pasteurella multocida
Pasteurella multocida is a Gram-negative bacterium that infects a wide range of hosts and can cause avian cholera,swine atrophic rhinitis,swine pneumonia,haemorrhagic septicaemia in cattle,sheep and rabbits.With the widespread use of antibiotics,the resistance of pathogenic bacteria is increas-ing every year.Studies in recent years have even more often found that pathogenic bacteria can develop strong resistance to β-lactams,macrolides,quinolones,tetracyclines,chloramphenicol and sulphonamide antibiotics.This paper summarizes the drug susceptibility and resistance mechanisms of Pasteurella mul-tocida to six types of antibiotics,providing a theoretical basis for the research of new drugs and the estab-lishment of novel therapies.

Pasteurella multocidadrug resistanceresistance mechanism

车笑吟、闫满、沙万里

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吉林农业科技学院动物科技学院,吉林吉林 132109

吉林省猪生态养殖及疫病防控科技创新中心,吉林吉林 132109

多杀性巴氏杆菌 耐药性 耐药机制

2024

家畜生态学报
西北农林科技大学

家畜生态学报

CSTPCD北大核心
影响因子:0.635
ISSN:1673-1182
年,卷(期):2024.45(3)
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