TRP家族调控黑色素的研究进展
Research Progress on TRP Family Regulating Melanin
张锦标 1高振东 1黄代涛 1陆颖 1李雯 1刘兴能 2岳丹 3邓卫东 1种玉晴1
作者信息
- 1. 云南农业大学动物科学技术学院,云南昆明 650225
- 2. 云南农业职业技术学院,云南昆明 650031
- 3. 玉溪农业职业技术学院,云南玉溪 653106
- 折叠
摘要
黑色素是由黑色素细胞产生的一种天然色素,也是构成动物颜色的主要成分之一.黑色素的形成过程涉及多个基因的调控,因此仍存在许多未知问题.瞬时受体电位(transient receptor potential,TRP)通道家族位于细胞膜,调节Ca2+、Mg2+等阳离子的摄入,这一功能对于TRP家族在黑色素沉着调节中具有重要意义.通过总结发现,TRPM1、TRPM2、TRPA1、TRPV1在黑色素调控中发挥关键作用,TRPM3可能参与黑色素调控.TRPM1通过Ca2+/CaMKⅡδ/AKT途径促进黑色素瘤的发展,在正常皮肤组织中可能通过p53-TRPM1/miR-211-MMP9途径调控黑色素沉着.TRPM2可能通过TRPM2-Ca2+-CaMKⅡ-ROS途径促进黑色素细胞死亡.TRPM3可能与miR-204协同调控黑色素.TRPA1通过促进F-肌动蛋白重塑和PAR-2/CYLD途径促进角质形成细胞中的黑色素体吞噬作用,并且TRPA1可能协同cAMP或NO信号通路来刺激黑素细胞中的黑素生成.本文总结了 TRP家族在黑色素细胞、黑色素瘤细胞和角质形成细胞中对黑色素调控的作用,为进一步揭示TRP家族对黑色素调节的机制提供参考.
Abstract
Melanin is a natural pigment produced by melanocytes,and also one of the main components of animal color.However,the process of melanin formation involves the regulation of multiple genes,so there are still many unknown problems.Transient receptor potential(TRP)channel family is located in cell membrane,which regulates the uptake of Ca2+,Mg2+and other cations.This function is of great sig-nificance for TRP family in the regulation of melanosis.It is found that TRPM1,TRPM2,TRPA1 and TRPV1 play key roles in melanin regulation,and TRPM3 may be involved in melanin regulation.TRPM1 promotes the development of melanoma through Ca2+/camkiii δ/Akt pathway,and may regulate melano-sis through p53-TRPMl/miR-211-MMP9 pathway in normal skin tissues.TRPM2 may promote melano-cyte death through TRPM2-Ca2+-CaMKⅡ-ROS pathway.TRPM3 may cooperate with miR-204 to regulate melanin.TRPA1 promotes melanosome phagocytosis in keratinocytes by promoting F-actin remodeling and PAR-2/CYLD pathway.Additionally,it may cooperate with cAMP or NO signaling pathway to stimu-late melanogenesis in melanocytes.This paper summarizes the role of TRP family in regulating melanin in melanocytes,melanoma cells and keratinocytes,which provides a theoretical basis for further revealing the mechanism of TRP family in regulating melanin.
关键词
黑色素/TRP家族/信号通路Key words
melanin/TRP family/signal pathway引用本文复制引用
基金项目
国家自然科学基金(3216200081)
云南省院士专家工作站(202105AF150043)
出版年
2024
国家科技期刊平台
NSTL
万方数据