As a major intestinal nutrient,butyric acid and its derivatives play an important role in main-taining animal intestinal morphology,regulating the environment of animal intestinal flora,and regulating immunity.Previous studies have shown that butyric acid and its derivatives maintain the intestinal micro-environment of animals mainly by promoting intestinal cell proliferation and affecting intestinal develop-ment,maintain the intestinal barrier by improving the expression of relevant proteins in small intestinal epithelial cells,and maintain the homeostasis of the internal environment by regulating the intestinal envi-ronment and stimulating the expression of relevant immune proteins.In terms of regulating energy metab-olism,butyric acid and its derivatives directively break down to become energy supply,or serve as an ener-gy intake regulator to affect energy metabolism by regulating related genes,mitochondrial synthetic repair and neural circuits.In addition,butyric acid and its derivatives act as signaling molecules in the immune pathway,regulate the gene and protein expression of immune factors,inhibit the proliferation of cancer cells,and improve intestinal immunity.This article mainly discusses the research progress of the mecha-nism of butyric acid in maintaining animal intestinal health,in order to provide theoretical reference for the development of butyrate products.
关键词
丁酸/肠道健康/微环境/能量代谢/免疫调节
Key words
butyric acid/intestinal health/microenvironment/energy metabolism/regulation of immu-nity
维普
万方数据