首页|Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

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Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe cases.In this study,oxygen vacancy(OV)defects Fe-doped TiO2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2 and Fe3O4 via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser sintering.The results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2 nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant site.The accumulated H2O2 could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(OH),thereby resulting in more bacterial deaths through OH-mediated oxidative damage.This antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(E.coli)and Gram-positive Staphylococcus aureus(S.aureus).In addition,the PCLGA/OV-FeTiO2 scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

bacterial infectionbone scaffoldselective laser sinteringFenton reactionantibacterial properties

Cijun Shuai、Xiaoxin Shi、Feng Yang、Haifeng Tian、Pei Feng

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State Key Laboratory of Precision Manufacturing for Extreme Service Performance,College of Mechanical and Electrical Engineering,Central South University,Changsha 410083,People's Republic of China

Institute of Additive Manufacturing,Jiangxi University of Science and Technology,Nanchang 330013,People's Republic of China

College of Mechanical Engineering,Xinjiang University,Urumqi 830017,People's Republic of China

国家自然科学基金国家自然科学基金国家自然科学基金湖南省自然科学基金Jiangxi Provincial Natural Science Foundation of ChinaProject of State Key Laboratory of Precision Manufacturing for Extreme Service PerformanceTechnology Innovation Platform Project of Shenzhen Institute of Information Technology(2020)Guangdong Province Precision Manufacturing and Intelligent production education Integration Innovation PlatformIndependent Exploration and Innovation Project of Central South University

5227539351935014820720842021JJ2006120224ACB204013PT2020E0022022CJPT0191053320220553

2024

10.1088/2631-7990/ad01fd

极端制造(英文)

极端制造(英文)

CSTPCDEI
ISSN：
年,卷(期)：2024.6(1)