Platelet/lymphocyte ratio and prognostic impact of livoxaban combined with catheter thrombolysis in elderly patients with acute upper extremity deep vein thrombosis complicating intracranial hemorrhage
Objective To analyze platelet/lymphocyte ratio(PLR)and prognostic impact of sandbath combined with catheter thrombolysis in elderly patients with acute upper extremity deep vein thrombosis(DVT)complicating intracranial hemorrhage.Methods Aged patients with intracranial hemorrhage combined with acute upper extremity DVTs admitted to our hospital from October 2018 to September 2022 were selected.Based on the inclusion and exclusion criteria,43 patients who took rivoroxaban orally after catheter removal were selected as the observation group,and 43 patients who received thrombolysis alone during the same period were selected as the control group.Clinical efficacy and PLR were evaluated and compared after treatment.Results The overall efficacy of 93.02%(40/43)was significantly higher in the observation group than in the control group(31/43)(χ2 =4.038,P<0.05).The levels of plasma D-D(D-dimer),FIB(Fibrinogen)and PLR in the observation group were significantly lower than those in the control group[(0.71±0.14)mg/L vs.(0.83±0.22)mg/l,(3.52±0.38)g/L vs.(4.37±0.42)g/l,(220.83±53.1)vs.(281.12±89.73)],prothrombin time(PT)and activated partial thromboplastin time(APTT)were significantly higher than those in the control group[(15.14±1.31)s vs.(14.18±1.52)s,(44.29±4.53)s vs.(40.28±4.17)s],the difference was significant(t=3.018,9.841,3.784,3.137,4.271,P<0.05).After 2 weeks of treatment,the limb circumference diameter and above the elbow in the observation group were significantly lower than in the control group[(1.52±0.23)cm vs.(1.83±0.27)cm,(1.02±0.12)cm vs.(1.69±0.35)cm](t=5.731,11.874,P<0.05).The incidence of adverse reactions was lower than in the control group,with no statistical significance(P>0.05).Conclusion Livoxaban combined with catheter thrombolysis is effective in the treatment of acute upper extremity DVT.The physiological mechanism of DVT formation is related to PLR,and PLR index is helpful for the evaluation of DVT's formation and prognosis.
Intracranial hemorrhage old ageAcute upper extremity deep vein thrombosisPlatelet/lymphocyte ratio
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