Effects of combined application of high-low frequency repetitive transcranial magnetic stimulation on neurotransmitter and motor function in patients with hemiplegia after cerebral infarction
Objective To investigate the effects of combined application of high-low frequency repetitive transcranial magnetic stimulation(rTMS)on neurotransmitter and motor function in patients with hemiplegia after cerebral infarction.Methods 105 patients with hemiplegia after cerebral infarction in our hospital from August 2019 to August 2022 were randomly divided into a low frequency group,a high frequency group and a combined group,with 35 cases in each group.On the basis of routine rehabilitation treatment,the low frequency group was treated with low frequency rTMS on the healthy side,the high frequency group was treated with high frequency rTMS on the affected side,and the combined group was treated with low frequency rTMS on the healthy side and high frequency rTMS on the affected side.The serum neurotransmitters[5-hydroxytryptamine(5-HT),dopamine(DA),brain-derived neurotrophic factor(BDNF)]levels,nerve conduction function[motor evoked potential(MEP)latency,center-motion conduction time(CMCT)]and limb motor function[Fugl-Meyer motor function scale(FMA)score,Berg balance scale(BBS)score,Barthel index]were compared between the two groups.Results There was no significant difference in all indexes among the three groups before treatment(P>0.05).After treatment,the levels of serum 5-HT,DA,BDNF and the FMA score,BBS score,Barthel index of the three groups were significantly increased,and the combined group were significantly higher than those of the low frequency group and the high frequency group(F=12.038,16.356,9.388,6.562,4.971,6.604,P<0.05).After treatment,the latency and CMCT of MEP in the three groups were shortened,and the latency and CMCT in the combined group were lower than those in the low frequency group and the high frequency group(P<0.05).Conclusion High-low frequency rTMS can stimulate the release of neurotransmitters and promote the recovery of limb motor function in patients with hemiplegia after cerebral infarction,and the effect is better than single frequency rTMS treatment.It can be used as an effective auxiliary treatment in clinic.
Cerebral infarctionHemiplegiaRepetitive transcranial magnetic stimulationMotor functionNeurotransmittersHemodynamics
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