Relationship between IL-1β,TNF-α and prognosis of patients with cerebral infarction
Objective To explore the relationship between IL-1β and TNF-α levels and the prognosis of patients with cerebral infarction.Methods A total of 136 patients with acute cerebral infarction diagnosed by clinical examination including imaging from January 2022 to December 2022 in our neurology department were selected as the study group,and 136 healthy volunteers from our hospital's health examination were selected as the control group.General data of both groups were collected,and the levels of IL-1β and TNF-α were compared along with NIHSS scores.Multifactorial logistic regression analysis was performed to analyze the relationship between the prognosis of cerebral infarction patients and IL-1β and TNF-α.Results Compared with the control group,the levels of IL-1β and TNF-α were significantly elevated in the study group(P<0.05),and there were significant differences in the levels of IL-1β and TNF-α between the recovery period and the acute period in the study group(P<0.05).NIHSS scores were negatively correlated with the severity of cerebral infarction and the levels of IL-1β and TNF-α(P<0.05).Multifactorial logistic regression analysis showed that elevated IL-1β and TNF-α levels were independent risk factors affecting the prognosis of acute cerebral infarction patients(P<0.05).The ROC result showed that the areas under the curve(AUC)of IL-1β and TNF-α elevation in predicting the prognosis of acute cerebral infarction patients were 0.758 and 0.768,with corresponding sensitivities of 82.43%and 65.13%,and specificities of 68.59%and 94.11%,respectively.The combined diagnostic AUC was 0.893,with sensitivities and specificities of 83.72%and 94.13%,respectively.Conclusion Serum IL-1β and TNF-α levels are elevated in patients with acute cerebral infarction,and both have certain relationships and diagnostic value for the prognosis of cerebral infarction patients.Furthermore the combined predictive diagnostic efficacy of both is better and can be widely used in clinical practice.
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