The association between hemoglobin and carotid plaque formation based on LASSO regression and Cox proportional risk model
Objective The aim of this study was to investigate the relationship between hemoglobin(HB)levels and carotid plaque formation.Methods The physical examination population database in 2014 was used as the baseline of the cohort,and the end point of the follow-up time was in 2020.The follow-up end-event is the onset of carotid plaque.The influencing factors of carotid plaque are screened by Lasso regression algorithm,The Cox proportional hazard model was used to analyze the association of HB and carotid plaque.Results A total of 977 people without carotid plaque were enrolled.After 6 years follow-up,326 cases of carotid plaque were recorded,and the cumulative incidence was 33.4%.When lasso regression screened 9 variables such as age and smoking,the root mean square error of the model was the smallest λ = 0.011 3.The LASSO regression model screening variables predicted the area under the curve of new carotid plaques by ROC,AUC was 0.762.The Cox proportional hazard model further verified that hemoglobin was an independent risk predictor of carotid plaque.Conclusion The high level of hemoglobin in the physical examination population may be related to the high incidence of carotid plaque.We should focus on the hemoglobin level of the middle-aged and elderly physical examination population,which may suggest that the population with higher nutritional levels is a key group for preventing and controlling new occurrences of carotid artery plaques.
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