The relationship between overlap syndrome and cardiovascular disease based on the NHANES database
Objective To explore the correlation between obstructive sleep apnea(OSA),chronic obstructive pulmonary disease(COPD)and overlap syndrome(OS)and cardiovascular diseases,so as to provide a basis for the prevention and control of OSA-COPD and cardiovascular diseases.Methods A total of 7 716 participants were included in this analysis using data from the 2005-2008 NHANES.According to the presence or absence of OSA and COPD,they were divided into four groups:no OSA and COPD group,OSA alone group,COPD alone group,and OS group.Multivariate logistic regression was used to explore the association between OSA,COPD,and OS and a variety of cardiovascular diseases.At the same time,the association between OSA,COPD and overlap syndrome and cardiovascular risk factors such as age,gender,obesity and cardiovascular disease in cardiovascular disease was explored.Results Compared with the non-OSA and COPD groups,the OS group had myocardial infarction(OR=2.85,95%CI= 1.94～4.21),congestive heart failure(OR=4.32,95%CI= 2.73～6.84),angina pectoris(OR=3.07,95%CI=1.92～4.91),stroke(OR=2.52,95%CI=1.61～3.97),and coronary heart disease(OR=3.1,95%CI=2.22～4.31)and the increased risk of cardiovascular disease(OR=3.43,95%CI=2.54～4.63).The incidence of stroke in the OSA symptom alone group was 1.46 times higher than that in the non-OSA and COPD groups(OR= 1.46,95%CI= 1.07～1.99),and the risk of congestive heart failure(OR=3.27,95%CI=1.77～6.07),coronary heart disease(OR=1.68,95%CI=1.03～2.73)and overall cardiovascular disease(OR=1.93,95%CI = 1.25～3.00)were also significantly increased.No association between isolated OSA symptoms and an increased risk of cardiovascular disease was observed.Associations of OSA,COPD,and overlap syndromes with overall cardiovascular disease,coronary heart disease,and myocardial infarction were stable across subgroups.Conclusion OSA-COPD syndrome is significantly associated with an increased risk of myocardial infarction,congestive heart failure,angina,stroke,coronary heart disease,and overall cardiovascular disease.Monitoring the occurrence of OSA-COPD overlap syndrome is of great significance for the prevention of cardiovascular diseases.
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