重组人脑利钠肽治疗急性心力衰竭的疗效观察
Therapeutic effect of recombinant human brain natriuretic peptide on acute heart failure
宋文廉 1崔颖 1肖家军 1孙飞 1吴刘巨1
作者信息
摘要
目的 分析急性心力衰竭(acute heart failure,AHF)应用重组人脑利钠肽(recombinant human brain natriuretic peptide,rh-BNP)治疗的效果.方法 选取 2021 年 1 月～2022 年 12 月蚌埠市中医医院收治的AHF患者 97 例,按入院顺序编号分组,对照组 51 例,观察组 46 例.对照组给予常规治疗,观察组在对照组基础上联合重组人脑利钠肽治疗,对比两组临床疗效、心功能、N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)及不良反应.结果 观察组总有效率95.65%较对照组 78.43%更高,差异有统计学意义(χ2 =6.179,P<0.05).治疗后,观察组左心室射血分数(left ventricular ejection fraction,LVEF)水平较对照组更高[(50.99±4.24)%vs.(43.56±4.71)%],左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end systolic diameter,LVESD)较对照组更低[(54.15±1.33)mm vs.(58.39±2.12)mm、(35.66±2.65)mm vs.(40.32±2.12)mm],差异有统计学意义(t=8.131、11.650、9.605,P<0.05).治疗后,观察组NT-proBNP水平较对照组更低[(779.59±59.71)pg/ml vs.(1157.59±80.56)pg/ml],差异有统计学意义(t=26.019,P<0.05).观察组不良反应发生率 17.39%,稍高于对照组 9.80%,但差异无统计学意义(χ2 =1.199,P>0.05).结论 AHF应用rh-BNP治疗,有利于改善心功能,促进疗效提高,且不会增加不良反应.
Abstract
Objective To analyze the therapeutic effect of recombinant human brain natriuretic peptide(rh-BNP)in the treatment of acute heart failure(AHF).Methods 97 cases of AHF patients admitted to Bengbu Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected and grouped into 51 cases in control group and 46 cases in study group according to the order of admission.The control group was given conventional treatment,while the research group was treated with recombinant human brain natriuretic peptide in addition to conventional treatment.The clinical efficacy,cardiac function,N-terminal pro-brain natriuretic peptide(NT-proBNP)and adverse reactions of the two groups were compared.Results The total effective rate of the comparison group was 95.65%,higher than that of the control group 78.43%(χ2=6.179,P<0.05).After treatment,the level of left ventricular ejection fraction(LVEF)in the study group was higher than that in the control group,the level of left ventricular end systolic diameter(LVEDD),left ventricular end systolic diameter(LVEDD)in the comparison group was lower than that in the control group(t=8.131,11.650,9.605,P<0.05).The level of NT-proBNP in the study group was lower than that in the control group(t=26.019,P<0.05).The incidence of adverse reactions in the comparison group was 17.39%,higher than 9.80%in the control group,but With no Statistical significance(χ2=1.199,P>0.05).Conclusion The application of rh-BNP in the treatment of AHF is beneficial to improve cardiac function,promote the improvement of curative effect,and does not increase the adverse reaction.
关键词
急性心力衰竭/治疗效果/重组人脑利钠肽/心功能/左室射血分数Key words
Acute heart failure/Therapeutic effect/Recombinant human brain natriuretic peptide/Heart function/Left ventricular ejection fraction引用本文复制引用
基金项目
安徽省医学会急诊医学会分会急诊临床研究计划(2021)(Ky2021003)
出版年
2024
NETL
NSTL
万方数据