Impact of atrial fibrillation burden on thrombotic events in patients with non valvular atrial fibrillation
Objective To observe the effect of different atrial fibrillation loads on the occurrence of thrombotic events in patients with nonvalvular paroxysmal atrial fibrillation.Methods Patients with paroxysmal atrial fibrillation admitted to our hospital were selected as the research subjects.Collect baseline clinical data of enrolled patients,and all patients underwent 7-day dynamic electrocardiogram examination.Based on the analysis result of the examination,the patients were divided into groups.Patients were divided into three groups based on the percentage of atrial fibrillation occurrence time in the overall recorded time.≥23%were defined as the high load group,7%～23%as the medium load group,and≤7%as the low load group.Follow-up will be conducted through outpatient and medical record systems,and patients will be followed up by phone once a year.Excluding patients who were lost in follow-up and underwent radiofrequency ablation,frozen balloon ablation,or left atrial appendage occlusion,a total of 153 patients completed follow-up,including 48 in the low load group,53 in the medium load group,and 52 in the high load group.The average follow-up was 42.7 months.Results There was no statistically significant difference in laboratory tests such as general information,basic medication,liver and kidney function,blood lipids,and LVD and LVEF among the three groups.The proportion of patients with a history of alcohol consumption in the medium load group was higher than that in the low load group and high load group,and the difference between the groups was statistically significant(P<0.05).The proportion of using digoxin in the high load group of atrial fibrillation was higher than that in the medium and low load group,and the difference between the groups was statistically significant(P<0.05).LAD increases with the increase of atrial fibrillation load.The high load LAD group is higher than the medium load group,and the medium load group is higher than the low load group.The difference between the two groups is statistically significant(P<0.05).As the burden of atrial fibrillation increases,the incidence of ischemic stroke/TIA and thrombotic events gradually increases.The incidence of ischemic stroke/TIA in the high load group is higher than that in the medium load group,and the medium load group is higher than that in the low load group.The difference between groups is statistically significant(P<0.05).The total thrombotic event incidence in the high load group is higher than that in the medium and low load groups,and the difference between groups is statistically significant(P<0.05).There was no statistically significant difference in the incidence of acute myocardial infarction and cardiovascular and cerebrovascular mortality among the three groups.There is a positive correlation between atrial fibrillation load and the main thrombotic endpoint event,with a correlation coefficient of 0.271.Conclusion The burden of atrial fibrillation is closely related to thrombotic events such as stroke.The heavier the burden of atrial fibrillation,the higher the incidence of major thrombotic events.
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