Application of high-flow nasal cannula oxygen therapy in patients with acute exacerbations of chronic obstructive pulmonary disease
Objective To explore the value of HFNC in patients with AECOPD.Methods A retrospective analysis was conducted on the clinical data of 66 AECOPD patients admitted and discharged from the respiratory department of Xiaolan People's Hospital from January 2021 to December 2022.All patients received respiratory support treatment on the basis of anti infection,cough relieving,phlegm resolving,and asthma relieving treatments.According to different respiratory support treatment method,they were divided into HFNC group(30 cases)and NPPV group(30 cases).Compare the vital signs,blood gas analysis of two groups of patients.The changes in blood gas analysis indicators of patients in the HFNC group were stratified based on age and oxygenation index.Results There was no statistically significant difference in heart rate,respiratory frequency,oxygen partial pressure,and oxygenation index between the two groups before treatment(P>0.05).There was no statistically significant difference in heart rate,respiratory frequency,oxygen partial pressure,and oxygenation index between the two groups after treatment(P>0.05).In the HFNC group,there was a statistically significant difference in heart rate,oxygen partial pressure,and oxygenation index before and after treatment(P<0.05);The NPPV group showed statistically significant differences in heart rate,respiratory frequency,oxygen partial pressure,and oxygenation index before and after treatment(P<0.05).Patients in the HFNC group were stratified based on age and oxygenation index.Compared with before treatment,patients aged 71 years and above with oxygenation index between 201～300 mmHg showed a significant increase in PaO2 and PaO2/FiO2 after treatment,with a statistically significant difference(P<0.05).Conclusion Both HFNC and NPPV can improve oxygenation function in AECOPD patients,with comparable effects and can be used as alternative options for NPPV.HFNC is particularly suitable for people aged 71 years and above,with PaO2/FiO2 between 201～300 mmHg.
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