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老年患者前列腺电切术后膀胱痉挛的危险因素分析及风险预警模型

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目的 探讨老年患者前列腺电切术(TURP)术后膀胱痉挛(BS)的危险因素,分析及建立预测风险预警模型。方法 回顾性选取 2021 年 1 月~2023 年 7 月濉溪县医院老年前列腺增生(BPH)患者 125 例,所有患者均行TURP。根据术后是否发生膀胱痉挛分为痉挛组(n=30)和非痉挛组(n=95),探讨影响术后膀胱痉挛的危险因素,使用单因素和多因素logistic回归构建预测风险模型。使用受试者工作特征曲线(ROC)、Homster-Lemeshow拟合优度检验(H-L)分别对模型进行性能评价。并另选 50 例患者临床资料进行模型外部验证。结果 125 例老年BPH患者行TURP后发生膀胱痉挛30 例,膀胱痉挛发生率 24。00%。单因素分析结果显示,两组视觉模拟疼痛(VAS)评分、术后留置导尿管时间、不稳定膀胱、尿管气囊注水体积、冲洗液温度、引流不畅、术后便对发生BS具有统计学意义(t=5。058、3。613,χ2 =14。214、13。697、14。803、10。201、9。868,P<0。05)。多因素logistic分析结果显示,高疼痛评分、术后留置导尿管时间过长、不稳定膀胱、尿管气囊注水体积 40 ml、冲洗液温<30℃、引流不畅、术后便秘是老年患者TURP术后发生膀胱痉挛的独立危险因素(P<0。05)。H-L检验结果显示,χ2=2。222,P>0。05;ROC曲线下面积(AUC)为 0。964(P<0。05,95%CI= 0。931~0。996),灵敏度为 96。70%,特异性为83。00%,最大约登指数为 0。83。而外部验证的H-L检验结果显示,χ2 = 7。191,P=0。516;AUC为 0。812(P<0。05,95%CI= 0。695~0。929),灵敏度为 76。70%,特异性为 75。00%,最大约登指数为 0。517。内外部模型拟合情况基本良好。结论 本研究构建的模型对老年患者TURP术后发生膀胱痉挛的预测效果良好,可为医护人员对行TURP术后膀胱痉挛高风险的患者时采取预防性措施提供参考。
Risk factors analysis and risk warning model of bladder spasm after transurethral resection of prostate in elderly frail patients
Objective To investigate the risk factors of bladder spasm(BS)after electro-prostatectomy(TURP)in elderly patients,and to analyze and establish a predictive risk early warning model.Methods A total of 125 elderly patients with benign prostatic hyperplasia(BPH)in Suixi County Hospital from January 2021 to July 2023 were selected as the study subjects retrospectively.All patients underwent TURP.According to whether bladder spasm occurred during the postoperative period,they were divided into spasm group(n=30)and non-spasm group(n=95)to explore the risk factors affecting postoperative bladder spasm.Univariate and multivariate logistic regression were used to construct a predictive risk model.The receiver operating curve(ROC)and Homster-Lemeshow goodness-of-fit test(H-L)were used to evaluate the performance of the model.The clinical data of 50 patients were selected for external validation of the model.Results The probability of bladder spasm after TURP in 125 elderly BPH patients was 24.00%.The result of univariate analysis showed that in both groups,VAS score,postoperative indwelling catheter time,unstable bladder,ureteral balloon filling volume,temperature of flushing fluid,poor drainage,and postoperative constipation were statistically significant in the occurrence of BS(t=5.058,3.613,χ2=14.214,13.697,14.803,10.201,9.868,P<0.05).According to the result logistic multivariate analysis,high VAS score,long time of indwelling catheter after operation,unstable bladder,40 ml of water injection volume of catheter balloon,<30℃of flushing fluid temperature,poor drainage and postoperative constipation were independent risk factors for bladder spasm after TURP in elderly patients.H-L test result showed that χ2=2.222,P>0.05.The ROC curve showed that the area under the ROC curve(AUC)was 0.964(P<0.05,95%CI= 0.931~0.996),the sensitivity was 96.70%,the specificity was 83.00%,and the maximum Youden index was 0.83.The H-L test result of external validation showed that χ2=7.191,P=0.516.The AUC was 0.812(P<0.05,95%CI=0.695~0.929),the sensitivity was 76.70%,the specificity was 75.00%,and the maximum Youden index was 0.517.The internal and external model fitting is basically good.Conclusion The model constructed in this study has a good predictive effect on bladder spasm after TURP in elderly patients,which can provide reference for medical staff to take preventive measures in time for patients with high risk of bladder spasm after TURP.

Elderly patientsTransurethral resection of the prostateBladder spasmRisk factorsRisk warning model

金梅、惠素芹、高淑玲

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235100 淮北,安徽省濉溪县医院泌尿外科

老年患者 前列腺电切术 膀胱痉挛 危险因素 风险预警模型

安徽省卫生健康科研项目

AHWJ2022a037

2024

中华保健医学杂志
中国人民解放军总后勤部卫生部保健局

中华保健医学杂志

CSTPCD
影响因子:0.477
ISSN:1674-3245
年,卷(期):2024.26(2)
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