首页|基于ROC曲线分析子痫前期孕妇血清EG-VEGF、NLR、PLR表达与病情严重程度的相关性

基于ROC曲线分析子痫前期孕妇血清EG-VEGF、NLR、PLR表达与病情严重程度的相关性

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目的 探讨子痫前期孕妇血清内分泌腺源性血管内皮生长因子(EG-VEGF)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)表达与病情严重程度的相关性。方法 回顾性分析 2021 年 10 月～2023 年 3 月在承德市中心医院妇儿院区产检的 90 例孕妇临床资料，根据是否患有子痫前期进行分组，将健康正常的30 例孕妇纳入健康对照组，将确诊为子痫前期的 60 例孕妇纳入观察组，且观察组根据子痫前期严重程度分为轻度组(n=30)和重度组(n=30)，比较健康对照组和观察组、轻度组和重度组的血清EG-VEGF、NLR、PLR表达水平，并应用ROC曲线分析血清EG-VEGF、NLR、PLR诊断子痫前期和评价病情严重程度的效能。结果 观察组的血清EG-VEGF、NLR高于健康对照组[(53。65±17。46)pg/ml vs。(28。93±9。37)pg/ml、(3。15±1。02)vs。(2。12±0。67)]，PLR低于健康对照组[(98。53±21。86)vs。(115。31±18。36)]，差异有统计学意义(t=7。237、5。010、3。613，P<0。05)。经ROC曲线分析发现，血清EG-VEGF、NLR、PLR诊断子痫前期效能良好(P<0。05)。重度组的血清EG-VEGF、NLR高于轻度组[(57。93±13。19)pg/ml vs。(49。63±15。63)pg/ml、(3。40±0。95)vs。(2。93±0。71)]，PLR低于轻度组[(163。72±35。41)vs。(146。70±28。63)]，差异有统计学意义(t=2。223、2。171、2。047，P<0。05)。经ROC曲线分析，发现血清EG-VEGF、NLR、PLR评价子痫前期病情严重程度的效能良好(P<0。05)。结论 子痫前期孕妇血清EG-VEGF、NLR呈高表达水平，PLR呈低水平表达，且病情越严重的孕妇血清EG-VEGF、NLR越高，PLR越低，且经ROC分析血清EG-VEGF、NLR、PLR在子痫前期和病情严重程度诊断评价方面效能良好。
Correlation between serum EG-VEGF,NLR,and PLR expression and disease severity in pregnant women with preeclampsia based on ROC curve analysis
Objective Correlation of serum endocrine gland-derived vascular endothelial growth factor(EG-VEGF),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)expression and disease severity in pregnant women with preeclampsia by application of subject operating characteristic(ROC)curve analysis.Methods We retrospectively analyzed the clinical data of 90 pregnant women who underwent obstetric examination in our hospital from October 2021 to March 2023,and grouped them according to whether they suffered from preeclampsia or not;30 healthy and normal pregnant women were included in the control group,and 60 pregnant women diagnosed with preeclampsia were included in the observation group,and the observation group was divided into a mild group(n=30)and a severe group(n=30)according to the severity of preeclampsia,and the expression levels of serum EG-VEGF,NLR,and PLR in the control group and the observation group were compared with the mild and severe groups.We compared the expression levels of serum EG-VEGF,NLR,and PLR in the control group and the observation group,and the mild group and the severe group,and analyzed the efficacy of serum EG-VEGF,NLR,and PLR in diagnosing preeclampsia and evaluating the severity of the disease by applying the ROC curve.Results Serum EG-VEGF and NLR in the observation group were higher than those in the control group,and PLR in the observation group was lower than that in the control group(t= 7.237,5.010,3.613,P<0.05),and ROC curve analysis showed that serum EG-VEGF,NLR and PLR were effective in diagnosing preeclampsia(P<0.05).Serum EG-VEGF and NLR in severe group were higher than those in mild group,and PLR in severe group was lower than that in mild group(t=2.223,2.171,2.047,P<0.05),and ROC curve analysis showed that serum EG-VEGF,NLR and PLR were effective in evaluating the severity of preeclampsia(P<0.05).Conclusion Serum EG-VEGF and NLR are highly expressed in preeclampsia pregnant women,while PLR is at a low level.The serum EG-VEGF and NLR are higher and PLR is lower in pregnant women with more severe disease.Moreover,serum EG-VEGF,NLR and PLR are effective in the diagnosis and evaluation of preeclampsia and the severity of the disease by ROC analysis.

PreeclampsiaPregnant womenSerum endocrine gland-derived vascular endothelial growth factorNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratio

娄艳慧、赵鸿雁、朱文丽

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067000 承德市中心医院妇儿院区产科

子痫前期 孕妇 血清内分泌腺源性血管内皮生长因子 中性粒细胞与淋巴细胞比值 血小板淋巴细胞比值

承德市科技计划

202102A014

2024

10.3969/j.issn.1674-3245.2024.02.028

中华保健医学杂志
中国人民解放军总后勤部卫生部保健局

中华保健医学杂志

CSTPCD
影响因子：0.477
ISSN：1674-3245
年,卷(期)：2024.26(2)
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