The effect of subcutaneous injection of low molecular weight heparin combined with non-invasive ventilation on peripheral blood Th17/Treg balance in AECOPD patients
Objective To investigate the impact of subcutaneous injection of low molecular weight heparin combined with non-invasive ventilation on the balance of peripheral blood helper T cell 17(Th17)/regulatory T cell(Treg)Th17/Treg in patients with acute exacerbation of chronic obstruc-tive pulmonary disease(AECOPD).Methods A total of 110 AECOPD patients admitted to our hospital from January 2021 to January 2023 were selected in the study.They were randomly assigned into either observation group(55 patients treated with subcutaneous injection of low molecular weight heparin combined with non-invasive ventilation)or a control group(55 patients treated with non-invasive ventilation)using a random number table method.The treatment effects of two groups of patients was compared.The peripheral blood Th17/Treg functional indicators,the changes in lung function and the adverse reactions between two groups of patients before and after treatment were als ocompared.Results The treatment efficacy of the observation group(96.36%)was significantly better than that of the control group(70.91%),and the difference was statistically significant(χ2=12.064,P<0.05);Following treatment,the Treg levels in the two groups of patients significantly increased,while the Th17 and Th17/Treg levels decreased.The Treg levels post treatment in the observation group were higher than those in the control group,while the Th17 and Th17/Treg levels were lower than those in the control group,with statistically significant differences(t=10.073,3.655,9.395,P<0.05);After treatment,the levels of forced vital capacity(FVC),arterial oxygen partial pressure(PaO2),first second forced expiratory volume(FEV1),and carbon monoxide diffusion volume(DLCO)in the two groups of patients significantly increased(P<0.05).After treatment,the levels of FVC,PaO2,FEV1,and DLCO in the observation group were higher than those in the control group,and the difference was statistically significant(t=5.186,4.048,4.982,3.509,P<0.05);There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ2=0.539,P>0.05).Conclusion Combining subcutaneous injection of low molecular weight heparin wth non-invasive ventilation effectively treats AECOPD patients.This approach regulates the Th17/Treg balance of patients,improve lung function,and merits clinical promotion and application.
Low molecular weight heparinNon invasive ventilatorAcute exacerbation of chronic obstructive pulmonary diseasePulmonary function
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