The relationship between TPO-Ab,FT3/FT4 ratio,TBiL level and short-term prognosis in patients with acute ischemic stroke
Objective To explore the relationship between thyroid peroxidase antibody(TPO-Ab),free triiodothyronine(FT3)and free thyroxine(FT4)ratio(FT3/FT4),serum total bilirubin(TBiL)level and short-term prognosis of patients with acute ischemic stroke(AIS).Methods A restrospective selection of 124 patients with acute ischemic stroke treated in the hospital from March 2021 to May 2023.Based on the modified Rankin Scale(mRS)score after 3 months of treatment,patients were categorized into good prognosis group or the poor prognosis group.Univariate and multivariate logistic regression analysis were employed to analyze the effects of Tpo-ab,FT3/FT4 ratio,TBiL level and other related factors on the short-term prognosis of patients with acute ischemic stroke,and the prediction model of poor prognosis of patients was constructed.The accuracy of the model was judged by ROC curve.Results There were 82 cases(66.13%)in the good prognosis group and 42 cases(33.87%)in the poor prognosis group.The age(OR=2.045,95%CI=1.159～3.608,P=0.014),NIHSS(OR=1.805,95%CI=1.058～3.079,P=0.030),TBiL(OR=0.620,95%CI=0.418～0.922,P=0.018),FT3/FT4(OR=0.244,95%CI=0.088～0.679,P=0.007),TPO-Ab(OR=3.242,95%CI=1.312～8.009,P=0.011)of the two groups were independent influencing factors of poor prognosis(P<0.05).On this basis,a risk prediction model was established.The model formula was Logit(P)=-42.915+0.715×age+0.591×NIHSS-0.477×TBiL-1.409×FT3/FT4+1.176×TPO-Ab.The area under the ROC curve was 0.996,95%CI=0.991～1.000,the sensitivity was 1.000,the specificity was 0.963,and the Youden index was 0.963.Conclusion TPO-Ab,FT3/FT4 ratio and TBiL level were identified as independent influencing factors for short-term poor prognosis in AIS.The established combined prediction model demonstrate good prediction efficiency for poor prognosis in patients with acute ischemic stroke.
Thyroid peroxidase antibodyThe ratio of free triiodothyronine/free thyroxineSerum total bilirubinAcute ischemic strokeShort-term prognosis
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